Modern methods of treatment and prevention of infectious diseases require the administration of antibiotics and antiseptics. Excessive and uncontrolled use leads to the selection of antibiotic-resistant strains of microorganisms, which dictates the need to find new alternative antimicrobial drugs. We searched for and studied the antimicrobial activity of new dimethylhydrazones. The compounds we studied showed significant antimicrobial activity, especially against gram-positive bacteria, S.aureus ATCC 25923 and lower antimicrobial activity against gramnegative bacteria, indicating the viability of these compounds and the need for more in-depth study of its antimicrobial activity on a wide range of microorganisms.