Резюме. З метою вивчення впливу ексенатиду на ультраструктурну організацію острівців підшлункової залози його вводили діабетичним щурам-самцям, починаючи з 14 доби розвитку стрептозотоцинового цукрового діабету. Забір матеріалу проводили на 28, 42, 56 доби експерименту. При медикаментозному лікуванні індукованого діабету спостерігали збільшення середньої площі острівців (мкм 2), середньої кількості острівців на 1 мм 2 , зростання співвідношення інсуліноцити/глюкагоноцити, відзначали появу малих острівців поблизу проток, часткове відновлення типової ультраструктурної організації ендокриноцитів підшлункової залози.

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Authors' contribution Wkład autorów: A. Study design/planning zaplanowanie badań B. Data collection/entry zebranie danych C. Data analysis/statistics dane-analiza i statystyki D. Data interpretation interpretacja danych E. Preparation of manuscript przygotowanie artykułu F. literature analysis/search wyszukiwanie i analiza literatury G. Funds collection zebranie funduszy Summary Venous thromboembolism is the third most common cause of vascular death after myocardial infarction and stroke, and is associated with considerable morbidity and premature mortality. The incidence of the most serious consequence of venous thromboembolism, fatal pulmonary embolism, ranges from 0.01% to 5% among hospitalised medical patients with multiple risk factors, and is currently considered the commonest avoidable cause of hospital death. rivaroxaban is a small-molecule factor Xa inhibitor that belongs to a new class of direct oral anticoagulant agents that directly inhibit single enzymes in the coagulation pathway. rivaroxaban has many advantages over vitamin K antagonists and unfractionated heparin and may become an alternative to traditional anticoagulant agents in patients at risk for thromboembolism. Moreover, antidotes exist and are in the progress of development, both specific and non-specific, for the treatment of overdose or side effects, including bleeding.

The work is devoted to the methodological features of the study of human anatomy by pediatric students. The experience of the department in teaching human anatomy in the light of the "Strategy for the development of medical education", taking into account the content of educational programs and current trends in digitalization of higher education in general and medicine in particular. The experience of application of interdisciplinary integration of curricula, accompanied by increasing the effectiveness of training of future pediatricians by giving practical lectures together with leading experts in propaedeutics of pediatrics, which allows as close as possible to modern requirements of the educational environment. And the use of computer testing has a training section that helps to master the material passed, and through the use of graphical tests, contributes to the visual formation of chains of interconnected processes. The issue of optimization of the educational process in medical educational institutions is relevant for the training of highly qualified personnel. In view of the above, classes with pediatric students require special attention of teachers of the department to ensure optimal conditions for the educational process using educational materials, visual aids, computer teaching aids, which allows to structure the student's cognitive activity to acquire the necessary in further knowledge and skills.