Introduction. The most important problems of clinical characterization and timely diagnosis of a new coronavirus infection COVID- 19 have been identified. The detection and treatment of patients with COVID-1 9 in the domestic health care system are carried out according to the Provisional Methodical Recommendations “Prevention, Diagnostics and Treatment of New Coronavirus Infection”. Its basic clinical manifestations are characterized by typical symptoms of acute respiratory viral disease: fever, dry cough, stuffy nose, headache, etc.Objective. To study the nature of clinical manifestations of new coronavirus infection COVID-1 9, associated with delta strain of SARS-CoV-2 coronavirus with moderate and severe course.Materials and methods. We analyzed the course of the disease in 50 patients treated as inpatients at Saransk Covid Hospital. Questionnaires to analyze complaints and anamnesis of diseases, data of medical records of in-patients were used. We used visual analog scale (VAS) to estimate the intensity of non-specific neurological disturbances, decreased sense of smell, taste and hearing, where 0 point means no neurological disturbance, 10 points – expressed disturbance. The presented data allowed to analyze the general, nonspecific and specific neurological manifestations of the new coronavirus infection COVID- 19 in the acute period in patients with moderate and severe course and to reveal their peculiarities.Results. At a moderately severe course of the disease, the characteristic symptoms of respiratory infection in combination with depressed mood and anxiety predominated. Of nonspecific neurological disorders, sleep disturbances, dizziness, and of specific manifestations, impaired sense of smell and taste prevailed. At a severe course the above symptoms were joined by myalgia, headache, dyspnea and shortness of breath, gastrointestinal disorders.Conclusions. The severity of the course of COVID-1 9 coronavirus infection, associated with the delta strain of SARS-CoV-2 coronavirus, is determined by the severity of the generalized manifestations, involvement of the lower respiratory tract, gastrointestinal disorders.

A new coronavirus infection (COVID-19, Corona Virus Disease 2019) is a disease caused by the SARS-CoV-2 virus, presenting as both a mild acute respiratory viral infection and a severe form, with damage to various organs and systems. In children under 16 years of age infected with SARS-CoV-2, the vast majority of cases were mild, without marked neurological manifestations.This paper describes a case of acute disseminated encephalomyelitis in a five-year-old child associated with SARS-CoV-2, which caused difficulties in the differential diagnosis with demyelinating diseases and hereditary pathology. The disease was diagnosed in a family where both parentswere diagnosedwith COVID-19 by polymerase chain reaction (PCR).The CNSlesionwasrepresented by severe central hemiparesis, involvement of some cranial nerves, with impaired pelvic organ function. During the treatment there was a positive dynamicsin the somatic and neurologicalstatus. The patient was discharged for outpatient treatment with satisfactory rehabilitation potential.SARS-CoV-2 lesions of the nervous system in children can lead to life-threatening and fatal conditions. Timely diagnosis and a comprehensive approach to the management of a child with encephalomyelitis made it possible to avoid adverse effects of the disease and improve the rehabilitation prognosis.