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The results of the investigation of the hypoglycemic action mechanism of N,N'-(ethane-1,2-dyyil)bis (quinoline-2-carboxamide) are presented. The substance was administered intragastrically in the dose of 11.64 mg/kg on the model of alloxan-induced diabetes mellitus in rats. It should be noted that the test compound in terms of the theory of pharmacophore can be considered as a dimer BU 224, but it is not its dimer in terms of organic chemistry. The information about the influence of the test compound on carbohydrate metabolism is limited. There are data that this compound has antitumor properties іn vitro due to enhanced apoptosis and activation of caspase-3. Proceeding from the chemical structure, the 2-substituted quinoline fragment is present in the structure of the known antagonist of imidazoline receptors I 2 such as 2-(4,5-dihydroimidazol-2-yl)quinoline hydrochloride, so it can be assumed that N,N'-(ethane-1,2-dyyil)bis(quinoline-2-carboxamide) has the ability to interfere with the mechanisms of the carbohydrate metabolism regulation. These results indicate that N,N'-(ethane-1,2-dyyil)bis(quinolin-2-carboxamide) has an expressed hypoglycemic effect in alloxan-induced diabetes mellitus reducing the blood glucose level by 71.50%. It is an agonist of imidazoline receptors of both types, and it has been proven by blockade with selective antagonists such as efaroxan and 2-(4,5-dihydroimidazol-2-yl)quinoline hydrochloride. On the background of I 1-imidazoline receptors blocker efaroxan the glycemia decrease was 45.66% (p<0.05), and on the background of I2-imidazoline receptors blocker 2-(4,5-dihydroimidazol-2-yl)quinoline hydrochloride it was 54.01% (p<0.05).

A method for calculating the refractive index of optical fused silica is proposed and realized. Fused silica is treated as a composite medium with nanopores in matrix with density differing from the crystalline quartz density. Maxwell Garnett model of effective dielectric permittivity is found to be accurate within 0.0002.The need for a detailed study of the optical and other physical properties of materials containing nanoparticles, i.e., particles with a radius a much smaller than the light wavelength is related to the development of the physics and technology of nanostructures, the formation of composites on their basis, and their practical application. Models of optically homogeneous medium [1, 2] with an effective permittivity (EP) are used to calculate the optical characteristics of materials with nanoparticles. EP and its dispersion depend on the nanoparticle permittivity , nanoparticle shape, the permittivity of the matrix (i.e., the medium containing nanoparticles), and the filling number of composite with nanoparticles q = Nv, where N is the concentration of particles and v is their average volume. 1 2Many studies devoted to various methods of preparation of nanostructures and analysis of their optical properties within EP models have been published recently (see reviews [3,4]). Transparent media (in particular fused silica and quartz films prepared by various methods) are used as matrices. Nanoparticles in these media are metal or semiconductor particles. It should be noted that the density and refractive index of optically homogeneous fused silica are much smaller than the corresponding parameters of crystalline -quartz, which indicates a high porosity of quartz glass. Both the densities and refractive indices of quartz glass and -quartz have been measured at room temperature with a high accuracy. The aforesaid gives grounds for an exact calculation of the quartz glass refractive index based on the data on the glass and -quartz densities and the refractive index of crystalline quartz within EP models.The problem of optical properties of nanocomposites is a part of the general problem of properties of mixtures of materials with different permittivities. Newton proposed the following simple formula to describe the EP of a mixture of two media with different permittivities and :1 2