Objective. To evaluate the results of surgical treatment of patients with cervical intraepithelial neoplasia (CIN) using excisional techniques and post-operative implementation of a quadrivalent human papillomavirus (HPV) vaccine. Patients and methods. Excisional treatment methods were used in 150 patients with CIN: 60 patients received a quadrivalent vaccine against HPV (type 6, 11, 16, 18) after surgery and 90 patients were not vaccinated. Post-operative examination was performed 3, 6, 12, 18, and 24 months after surgery and annually thereafter. Detection of CIN within 12 months after surgery was considered as a residual lesion, and more than 12 months after surgery – as a recurrence of the disease. Results. The post-operative follow-up periods for the vaccinated patients ranged from 6 to 93 months (median: 34 months), without vaccination: 6 to 202 months (median: 54 months). Residual lesions were not revealed among vaccinated patients and were revealed in 13.3% (12/90) of unvaccinated patients (p = 0.039). Recurrence of CIN among patients with follow-up for 12 months or more was noted in 3.3% (2/60) of vaccinated patients and 34.6% (27/78) of unvaccinated patients (p = 0.016). Conclusion. Vaccination against HPV (types 6, 11, 16, 18) after excisional treatment methods has significantly (approximately ten-fold) reduced the probability of CIN recurrence and may be considered as an effective approach to improve the results of treating patients with CIN. Key words: human papillomavirus, cervical intraepithelial neoplasia, vaccine, excisional treatment methods

Cervical intraepithelial neoplasia (CIN) refers to precancerous changes in the cervix. After surgical treatment, a certain proportion of patients remain at risk of disease reccurence. Therefore, monitoring of patients after CIN surgery is an important and necessary part of their management tactics. Objective. Review of world literature on modern approaches to patients monitoring after using excisional methods of CIN treatment. Materials and methods. The information material includes data from scientific articles on the subject available in Pubmed and published over the past 20 years. Results. The analysis of data contained in modern literature on the frequency and risk factors for the development of reccurent CIN after excisional methods of treatment, diagnostic methods, the timing of follow-up examinations during post-operative monitoring, the main approaches to monitoring in different countries and the effectiveness of the proposed strategies for postoperative follow-up of patients after treatment was conducted. It was established that the approaches to the observation of this category of patients differ in various countries. Almost everywhere, the priority tool for monitoring of patients with CIN after treatment is a combined test, which involves a joint use of cytology and human papillomavirus tests. The main difference between countries is the timing of the first post-treatment follow-up visit. In some countries a follow-up visit is recommended within 24 months, while in others it is suggested to return to routine screening if the primary combined test is negative. Conclusion. Despite existing disagreements, the proposed post-operative monitoring strategies for CIN patients provide a fairly high percentage of “healing” and return to routine screening. Key words: human papillomavirus, monitoring, cervical cancer, cervical intraepithelial neoplasia, excisional treatment

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