Simulations of competition between A and D for binding to two sites at a receptor reveal that the potencies of muscle relaxants, defined by IC50, and the slopes of the NMB vs. [D] curves depend on (1) the affinities of D for the two binding sites, (2) the orientation of the affinities relative to those of A, and (3) the affinities of A for the same two sites.

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Phenytoin acutely augments the neuromuscular block produced by rocuronium without altering its plasma concentration or its binding to plasma proteins.

I. L . J a n u a r 196 5 K F K 295 Y I n s t i t u t f ü r S t r a h l e n b i o l o g i e R e t e n t i o n o i R a d i o c a e s i u m b~ t h e R a t a s I n f l u e n c e d b \ $ 1. INTROD~CTION 13'Cs nlust be considered as a potentially hazardous radionuclide and a considerable amount of b o f k~ has been done aiming a t the enhancement OS 137Cs-excretion. Slightly higher urinary excretion rates were observed by Kurlandskaya (1957) arid Ogawa, &fachida, Suzuki and Shibata (1938) following the administration of stable Cs-salts; however, 3loskalev (1961 b) fttiled to confirm this finding. The excretion of 13'Cs in rats was enhanced by increasing the potassium content of the diet (Richmond and Furchner 1961 b, Wasserman, Comar and Tapper 1963); a similar effect, however, hus not been observed in humans (McKeill, Green and Rapoport 1962). The failure of the chelating EDTAto raise the urinary e~cretion (Fateyeva, Klimov, Ponizovskaya, Gorbarenlro; Sokolov and Smirnova 1960) is not surprising, due to the poor CO-ordinating properties of the alkali meta1 ions. Continuous administration of the diuretic Diamox reduced the body burden of 13iCs in small rodents to approximately 70% of the control (Richmond and Furchner 1961 a); however, in humans dillretics proved

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