Background-Presence of Human Leukocyte Antigen (HLA) B*57:01 allele predicts hypersensitivity reaction (HSR) to Abacavir (ABC), a nucleoside reverse transcriptase inhibitor used for HIV treatment. However, prevalence of this allele among Nigerians with HIV is yet to be established. We aimed to determine the prevalence of HLA B*57:01 allele among Nigerians with HIV infection.Methods-We conducted a multicenter cross-sectional epidemiologic survey. Between April 2016 and April 2017, patients were enrolled across 5 HIV treatment facilities in Nigeria. Participants' demographic information and history of ABC exposure were obtained, and venous blood obtained for HLA typing.Results-One thousand five hundred and four (1,504) adults were enrolled, with a mean age of 44.6 ± 10.7 years, 1,078 (71.7%) were female. 1,463 (97.3%) were on antiretroviral therapy. ABC use was reported by 12 (0.8%) participants and none reported HSR. Of 1,500 blood samples that

The three major ethnic groups of Nigerian population namely the Hausa, Igbo and Yoruba make up 29, 21 and 18% of the total population, respectively. To provide genetic information necessary for forensic analysis, this study was carried out to determine STR allele frequencies in 102 Hausa, 128 Igbo and 134 Yoruba individuals in Nigeria using 21 STR loci including the 20 CODIS (Combined DNA Index System) loci plus SE33.

In the original paper author Alani Sulaimon Akanmu was erroneously omitted from the author list. Prof. Akanmu has now been added as 4 author. Prof. Akanmu acted as an academic supervisor of the study and additionally contributed to the publication by reading, commenting and editing the manuscript.

Genetic insight into Nigerian population groups using an X chromosome decaplex system

Nigeria is a country located in Gulf of Guinea, in West Africa, facing the Atlantic Ocean. It is one of the most populous country in the world. There are more than 500 ethnic groups inhabiting the territory, representing a high diversity of languages and cultures. In this study, we collected 142 samples from the three largest ethnic groups in Nigeria: Hausa, Igbo and Yoruba. These samples were typed for the 27 Y-STR loci included in the Yfiler ® Plus kit. A total of 140 different haplotypes were found, with two haplotypes shared by 2 individuals. The haplotype diversity was 0.9998 ( ± 0.0009), slightly higher than that obtained with the 17 Y-STRs from the Yfiler kit (0.9992 ± 0.0010). The Yfiler kit also showed an increased number of shared haplotypes, with 4 being shared by 2 individuals and one by 3. The average gene diversity over loci was lower in Nigeria than in the U.S. population groups reported in Yfiler ® Plus kit User Guide. The DYS391, DYS390, DYS438, DYS392, DYS437 and DYS533 showed low diversity values (GD ≤ 0.35). Comparisons between Nigeria and five populations in East Africa, the only African data available for the Yfiler ® Plus markers, revealed significant differences among all populations (p-values ≪0.00005). The smallest F ST was found with Kenya (F ST = 0.025), followed by Ethiopia (F ST = 0.105). As expected, distances with Djibouti, Eritrea and Somalia were higher that 20%, since our sample are from Bantu speakers, not represented in these population sample.