Data on the biological activities of compounds containing m-dinitroaromatic (m-DAr) moieties were presented and led to the conclusion that including this moiety in the structures of new biologically active compounds was promising. It was established that one nitro group in m-DAr could be replaced by trifluoromethyl without losing the biological activity of the obtained analogs.Biologically active compounds with m-dinitroaromatic (m-DAr) moieties and examples of their use in medicine, veterinary medicine, and agriculture were reviewed. Compounds with m-DAr moieties were historically first used broadly as herbicides, fungicides, insecticides, and acaricides. Information about their activities was published in several monographs [1 -4]. 2,4-Dinitrophenols (I) were some of the first m-DAr compounds to find practical application as weed killers (Table 1).
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