No abstract

Surgical site infection (SSI) is a frequent complication of surgical procedures. The aim of this study was to analyze the clinical evidence for SSI prevention with triclosan-coated sutures (TCS) in abdominal surgery and to investigate the economic impact of TCS in this type of procedure compared with conventional absorbable sutures (CS). A literature review was carried out to identify meta-analyses that were published between 1990 and 2019 that assessed the use of TCS in abdominal surgery. A budget impact analysis was performed from an Italian hospital perspective based on the most recently published evidence to simulate the financial impact of TCS in a general surgery unit. Uncertainty was explored through scenario analysis, as well as deterministic and probabilistic sensitivity analyses. Nine meta-analyses and two additional randomized clinical trials were retrieved. All meta-analyses described a reduction (range 19%–44%) in the risk of SSI when TCS were used. The use of TCS was associated with an overall annual net saving for the general surgery unit of €14,785 and a reduction of 3.2 SSIs compared with CS. Sensitivity analyses resulted in a positive annual saving associated with TCS in 98% of scenarios. TCS are a valuable, cost-saving SSI prevention strategy. TCS additional costs would be offset by the reduction in SSIs.

A595 the increased demand for TKAs, there is a need for meaningful innovation that improves clinical outcomes and optimises resource utilisation. The DePuy Synthes (DS) ATTUNE® Knee System has been designed to improve patient function and satisfaction. The objective of this study was to compare the length of stay (LOS) for TKA patients who received ATTUNE versus the DS SIGMA® Knee System. Methods: A single center, retrospective analysis was conducted between 2013 and 2015 at a private Italian hospital. 200 consecutive patients from a single surgeon underwent TKA, representing the last 100 SIGMA cases and first 100 ATTUNE cases (post 20 learning curve cases). The primary endpoint was LOS. Electronic medical records were used to collect patient characteristics: age, gender, marital status, ASA grade, prior TKA, and pre-operative Oxford Knee Scores (OKS). Bivariate analyses to compare patient characteristics by implant were generated and a linear regression model was constructed to evaluate LOS as a function of demographic and clinical variables. Results: Patients implanted with ATTUNE demonstrated a 4-day reduction in mean LOS (95% CI 3.5-4.5 p< 0.0001): ATTUNE: 9.7 (SD: 1.2); SIGMA: 13.7 (SD: 1.9). There were no significant differences in reported characteristics between the two groups. The proportion of females (71%) was similar; there were no significant age differences with most patients between 61 and 70. Most patients were married (ATTUNE: 92%, SIGMA: 85%). All patients (100%) had severe preoperative OKS (ATTUNE: mean= 9.5 (SD: 3.7), SIGMA: mean= 9.4 (SD4.1)), and 22.5% patients had previous contralateral TKA (ATTUNE: 23%, SIGMA: 22%). ConClusions: Statistically significant differences were noted in the LOS between the two groups. This Real World study demonstrates how the adoption of ATTUNE could potentially benefit providers, payors and patients by reducing LOS.

patients resistant to first-line therapy by 6.9% and increased the percentage of patients with an overall clinical cure by 3.04%. Conclusions: CAZ-AVI was cost-effective as a first-line intervention for patients with cIAI caused by E. coli, K. pneumonia, or P. aeruginosa in Taiwan.

Probabilistic sensitivity analysis supported the original findings. Conclusions: Hospital-based nutrition programs can improve the health outcomes and reduce healthcare costs of malnourished hospitalized patients, whilst helping hospitals in Colombia with healthcare resource management to provide optimal quality of nutrition care to their patients at a reduced overall cost. These results provide a rationale for implementation of comprehensive nutrition programs for the malnourished hospitalized Colombian population.