Pyodermas are infectious skin diseases, prevailing in morbidity patterns of all categories of RF military men. The optimal etiotropic substance for the treatment of pustular diseases is carried out, while taking into consideration the data on excitors’ sensitivity. Mupirocin is a topical antibacterial substance, which activity is equivalent to the activity of peroral antibiotics Target - Migrative evaluation of the efficiency of 3% of tetracycline ointment and 2% of mupirocin ointment (supirocin) in the treatment of patients with pyoderma. Маterial and methods. 60 patients with initial pyodermas were examined, before and after the course of treatment the bacteriological research of erosions’ secretion was performed. Patients were undergoing the monotherapy with topical antibacterial substance 2 times a day: 2% mupirocin ointment in the 1st group and - 3% of tetracycline ointment in the 2nd group. After the regress of eruptions terms and efficiency of the treatment were assessed. Results. The topical antibacterial therapy of pyodermas with 2% mupirocin ointment is more effective than with 3% tetracycline ointment, - 40 (100%) of patients against 16 (80%) of patients, (р < 0,01). The use of 2% mupirocin ointment allows to decrease considerably terms of treatment of patients with pustular skin diseases in comparison with application of 3% tetracycline ointment (8,1 ± 1,8 and 12,2 ± 3,2 days accordingly, р < 0,01). 2% mupirocin ointment has got high clinical efficiency and can be recommended for the therapy of patients with pyodermas.