Background & objectives: There are limited data from India on the post-COVID multisystem inflammatory syndrome in adults (MIS-A). The objective of the present study was to evaluate the clinical profile of patients with MIS-A admitted to a tertiary care centre in southern India. Methods: This single-centre retrospective study was conducted from November 2020 to July 2021, and included patients aged >18 yr admitted to the hospital as per the inclusion and exclusion criteria. Results: Nine patients (5 male, mean age 40±13 yr) met the criteria for MIS-A. Five patients had proven COVID-19 infection or contact history 36.8±11.8 days back. All patients were positive for SARS-CoV-2 IgG antibody, negative for COVID-19 PCR, and had negative blood, urine and sputum cultures. All patients had fever and gastrointestinal (GI) symptoms, and five patients had left ventricular dysfunction. All patients had neutrophilic leucocytosis at presentation and elevated biomarkers such as C-reactive protein serum procalcitonin, D-dimer and ferritin. The majority of the patients (7/9 i.e . 77.78%) were treated with intravenous hydrocortisone (50-100 mg q6h-q8h). Six patients recovered completely whereas three patients expired. Interpretation & conclusions: Fever and GI symptoms were the most common presentation of MIS-A. Elevated serum procalcitonin may not be useful in differentiating bacterial sepsis from MIS-A. Most patients responded to corticosteroids.

Dengue, an arboviral infection is a notifiable disease in India and is endemic in many regions of the country. CRP levels help in knowing the severity of the disease. Patients with signs and symptoms of Dengue were included in the study. Their demographic data was noted. Serum was tested for NS1 ELISA, IgM ELISA. Positive samples were tested for CRP levels. Platelet count and Blood transfusion data was noted. Dengue positivity was 21%, with male predominance (55.6%), common in young children and teens. CRP level of 12 mg/L was seen in 28.40% of patients. Patients with CRP of 48mg/L required multiple platelet transfusion. Our study has correlated dengue positive patient's platelets, CRP levels and need for blood transfusion.

Surveillance of device-associated hospital-acquired infections(DA-HAI)in ICUs plays a vitalrole in hospitalinfection control&quality assurance and in understanding the changing trend and implementation ofthe antibiotic stewardship program.There islimited data on DA-HAIreported from Indian ICUs. The single-center study aimed to assess the burden, microbiologic prole, and the trend of DA-HAIs over ve years based on active monthly surveillance data as a part of Infection control practices in a tertiary care hospital in South India. DA-HAI rates of ventilator-associated pneumonia (VAP), central line-associated bloodstream infection (CLABSI), and catheter-associated urinary tract infection (CAUTI) per 1,000 device-days were calculated by dividing the total number of DA-HAIs by the total number ofspecic device-days and multiplying the result by 1,000. Overall DA-HAI rate of 1.46 per 1000 device days of whichCLABSI andVAP andCAUTI constituted 2.19, 2.09, and 0.42 per 1000 device days,respectively. Diabetes was the most common comorbidity associated with DA-HAI. In contrast to data from West gram negative organisms constituted the majority of etiological agentsin DA-HAIsregardless of the duration in ourstudy (82.45%), while gram positive organisms and fungi constituted only 17.54% & 0.87%, respectively. Notably, 96.15% of Acinetobacter baumannii isolates in VAP were carbapenem resistant (CR), while 54.54% Klebsiella pneumoniae wereCR. InCLABSI 75% of Enterococcusisolates were vancomycin resistant (VRE). InCAUTI 20% of gram negative organisms were CRandallEnterococcusfaeciumisolatesinwereVRE.TherewasincreasingtrendofCRgramnegativeorganisms causingDA-HAI.