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Funding Acknowledgements Type of funding sources: Other. Main funding source(s): Hellenic Society of Cardiology Background/Introduction: Transthoracic echocardiography is the most widely used imaging modality for the assessment of left ventricular ejection fraction (LVEF), which is crucial for patient care and management. Most recently, artificial intelligence (AI) has been employed to automatically identify LV endocardial boundaries and calculate LVEF. Technological advancements have enabled the development of small handheld ultrasound devices (HUDs) that can provide echocardiographic images at the point of care; however until now the HUDs have presented limited quantification capabilities. The application of AI algorithms to point-of-care echocardiography may facilitate the acquisition and accurate interpretation of a high volume of imaging data in real-time. Purpose To evaluate the accuracy of a novel HUD with AI-assisted algorithm (autoEF) to automatically calculate LVEF. Methods  We prospectively included consecutive patients who were referred to a tertiary hospital echocardiography laboratory for a standard echocardiography examination. The modified biplane Simpson’s method was used to determine LV volumes and function from the apical four-chamber and apical two-chamber views. All patients were subsequently scanned with the Kosmos HUD and a fully automated estimation of the LVEF was possible after acquisition of the same two apical views within seconds by the device itself with the use of the AI-assisted autoEF algorithm. The image quality for each examination was assessed and classified as good, moderate and poor. The autoEF measurements were compared head-to-head with the manually traced biplane Simpson’s rule measurements on cart-based systems as the reference standard, using linear regression and Bland-Altman analysis. Results The study comprised 100 consecutive patients (57 ± 15 years old, 61% male), including 38 patients with abnormal LVEF < 50%. The image quality for the cart-based systems acquisition was assessed as good in 45%, moderate in 50% and poor in 5% of patients and for the HUD acquisition as good in 31%, moderate in 57% and poor in 12% of patients. AutoEF measurement by AI-assisted algorithm was feasible in all patients with LVEF measurements on cart-based systems. There was good agreement between the reference standard and Kosmos autoEF algorithm with a correlation coefficient r = 0.87, 95%CI 0.81-0.91, (p < 0.0001). The corresponding Bland-Altman plot showed a small non-significant bias of -1.42% (p = 0.058), with limits of agreement ±14.5% for the auto-EF. The paired comparison of the LVEF calculation by the 2 methods did not reveal a significant difference between reference standard and HUD autoEF [56% (IQR 40% - 62%) vs 53% (IQR 43% - 59%) respectively, p = 0.106]. Conclusion The AI-assisted autoEF algorithm in a novel HUD can accurately calculate LVEF in real-time as compared to the recommended manual biplane Simpson’s method on cart-based systems in an "all-comers" patient population. Abstract Figure. Correlation plot for LVEF measurements  Abstract Figure. Bland-Altman plot

Pulmonary hypertension (PH) is a disorder with sometimes a challenging diagnosis, which can be made only by right heart catheterization. The role of echocardiography in the work-up of these patients is manifold. Its main contribution is in the assessment of the presence of PH in the setting of a clinical suspicion and thus it serves as a gatekeeper to avoid unnecessary invasive catheterizations. In this regard, estimation of pulmonary artery pressure is a central but not the only component that should be pursued, since there are many other additional echocardiographic features that can help the clinician to estimate the probability of the presence of PH more accurately and to fully assess its pathophysiological consequences. In addition, echocardiography can offer invaluable insight into right ventricular size and function, which is the cardiac chamber that is mainly affected by the disease and finally, it can provide important clues about the cause of PH and mainly help identify patients with pulmonary venous hypertension, in which treatment is entirely different from patients with precapillary hypertension. This review summarizes the echocardiographic findings commonly observed in patients with PH and focuses on important features that allow the clinician to exploit the full potential of this modality when assessing these patients.Answer questions and earn CME: https://wileyhealthlearning.com/Activity2/ 6463560/Activity.aspx