Garlic ( Allium sativum L.), is a predominant spice, which is used as an herbal medicine and flavoring agent, since ancient times. It has a rich source of various secondary metabolites such as flavonoids, terpenoids and alkaloids, which have various pharmacological properties. Garlic is used in the treatment of various ailments such as cancer, diabetes and cardiovascular diseases. The present study aims to explore the plausible mechanisms of the selected phytocompounds as potential inhibitors against the known drug targets of non-small-cell lung cancer (NSCLC). The phytocompounds of garlic were identified by gas chromatography-mass spectrometry (GC–MS) technique. Subsequently, the identified phytocompounds were subjected to molecular docking to predict the binding with the drug targets, epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) and group IIa secretory phospholipase A2 (sPLA2-IIA). Molecular dynamics is used to predict the stability of the identified phytocompounds against NSCLC drug targets by refining the intermolecular interactions formed between them. Among the 12 phytocompounds of garlic, three compounds[1,4-dimethyl-7-(1-methylethyl)-2-azulenyl]phenylmethanone, 2,4-bis(1-phenylethyl)-phenol and 4,5–2 h-oxazole-5-one,4-[3,5-di-t-butyl-4-methoxyphenyl] methylene-2-phenyl were identified as potential inhibitors, which might be suitable for targeting the different clinical forms of EGFR and dual inhibition of the studied drug targets to combat NSCLC. The result of this study suggest that these identified phytocompounds from garlic would serve as promising leads for the development of lead molecules to design new multi-targeting drugs to address the different clinical forms of NSCLC.

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Groundnut is an important edible oilseed crop of our country and edible oil economy primarily depends upon groundnut production. Secondary and micronutrient fertilization is essential for enhancing the productivity of groundnut crop. Calcium, Magnesium and Sulphur requirements are highest in oil seed crops followed by pulses and least in cereals. The response of groundnut to secondary and micronutrients was studied on sandy loam soils. Combined foliar application of secondary and micronutrients along with RDF recorded significantly highest pod yield of 2654 kg ha-1 and haulm yield of 3603 kg ha-1 as compared to RDF (1500 and 2551 kg ha-1 of pod and haulm yield, respectively) and also the highest uptake of primary nutrients (N, P and K) by haulm and pod at harvest which might be because of highest dry matter production with the combined application of all the nutrients.

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