The article presents a method of surgical treatment that may be used for therapy of diabetic osteoarthropathy in the cases of complete loss of support ability of limbs due to purulent complications: total purulent destructive osteoarthritis of the ankle joint, panflegmona involving the middle and posterior skeletal sections of the foot (patent application No. 2014142790 dated 23.10.2014). The method is in two-stage surgical treatment of this category of patients. The 1st stage is guillotine amputation of the lower third of the shin that allows removing the purulent center, which causes severe intoxication in patients and determines, in particular, the severity of their condition, radically, completely and quickly (within 5–7 min), and significantly reducing intraoperative blood loss and "energy loss" through the wound in the postoperative period (the small size of the wound with guillotine amputation), which leads to rapid recovery in the postoperative period; as well as stopping swelling of the leg as soon as possible and creating the conditions for reamputation with saving of the knee joint. The 2nd stage is reamputation of the affected extremity on the border of the upper and the middle third of the shin with the fasciomyoplastic method as a scheduled surgery. Due to application of the two-staged surgical, it is possible to prevent development of generalization of the infection and death, save the knee joint, reduce the rehabilitation period, and significantly improve the quality of life of patients.