Objective of the Paper: To demonstrate a clinical case of a severe course of the novel coronavirus infection with the development of cardiovascular complications against the background of concomitant comorbid diseases. Key points. A case of a novel coronavirus infection is presented with a description of the clinical course and the results of laboratory and instrumental examination. In the clinical picture, in addition to massive damage of the lung tissue, according to computed tomography, firsttime ischemic stroke, atrial fibrillation, and type 2 myocardial infarction were observed, which occurred against the background of obesity, type 2 diabetes mellitus and autoimmune thyroiditis. Conclusion. The polymorphism of the clinical picture and the various variants of manifestation of a novel coronavirus infection, taking in some cases a polysystemic character, require doctors to diagnose the disease in a timely manner and identify its potential complications at an early stage, developing in the acute period, especially in the older age group. Keywords: novel coronavirus disease, SARS-CoV-2, atrial fibrillation, ischemic stroke, type 2 myocardial infarction.