Mechanism of the synthesis of phosphoramidates by Todd-Atherton reaction is based on the primary interaction of a polyhaloalkane with the highly basic amine to form a 1:1 associate. The subsequent attack by the associate on the hydrophosphoryl compound of "symmetric" structure leads to the formation of the target compounds in high yields. The test of the effect of dialkyl hexamethylene-and dialkyl(pyridin-2-yl)-phosphoramidates in vitro against the strains of a number of the producents of pathogenic bacteria and mycotoxins showed that the high level of biological activity of the target compounds is correlated well with the physicochemical parameters characterizing their structure.Organic phosphoramidates exhibit a wide spectrum of biological action, from pesticides to anticancer drugs. The reasons for such diversity are different, and include high alkylating ability of phosphoramidates, their propensity to both spontaneous and enzymatic hydrolysis, and the ability of molecules with a P-N bond to insert in the structure of natural nucleotides [1][2][3].In this work we studied the mechanism of formation and biological action of some phosphoramidates:

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