Biological polymers have a preferred chirality ond can replicate themselves. Physical arguments provide insight into which of these unique and apparently related properties evolved first, and by what mechanism.

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This work discusses the question about the role of chirai purity ~omochi~lity) of nucleotides in the formation of complementary replicas. A qualitative answer to this question can be obtained from molecular models constructed to simulate the chiral defect in the polynucleotidic chain. It shows the necessity of homochirality of nucleotides for the complementarity preservation. The necessity of the strong mirror-symmetry breaking in the abiogenic formation of the self-replicating oligonucleotide structures is discussed in the context of p~biolo~c~ evolution. Polynucleotide Chiral purity Compiementarity

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