The article presents data on post-covid disorders of internal organs and systems with an emphasis on involvement in the pathological process of the gastrointestinal tract. The authors showed a high frequency of grastroenterological changes detected endoscopically: GERD of varying degrees of manifestation - 63%, inflammatory changes in the stomach (superficial, atrophic, hemorrhagic, erosive gastritis) - in 46%, damage to the duodenum and jejunum - in 12% and inflammatory changes in the ileum - 9% in the form of hemorrhages of varying degrees of prescription against the background of edematous pastous hyperemic folds, of which 4% had single or multiple erosions up to 3 mm, located in different parts of the small intestine, and 20% had lymphangiectasia of varying severity (in 4% of them in the form of “confluent fields” over several segments of the small intestine), epithelial formations of the upper gastrointestinal tract (hyperplasia, early cancer, GIST, neuroendocrine formations) - in 11%, inflammatory diseases of the colon (CD, UC) - in 4%, epithelial formations of the colon - 17%, diverticula of the colon - 8%. In 3 patients, solitary colon ulcers were found, located in the sigmoid and rectum. The effectiveness of the inclusion in the complex therapy of the recombinant interferon alfa 2-b in combination with vitamins E and C of post-covid changes in the gastrointestinal mucosa, especially solitary ulcers, has been shown