The studies were conduct in 2012-2018 on meadow chernozem soil in the conditions of the south of Western Siberia. The purpose of the study was to study the effect of zinc and copper fertilizers on the chemical composition of perennial medicinal plants in the zonal soil-climatic conditions of Western Siberia. The objects of study were Achillea millefolium L., Tanacetum vulgare L. and Echinacea purpurea L. Zinc and copper fertilizers were applied in MAC fractions: 0.25, 0.50, 0.75, and 1.0 on the grounds N135P45K45 (A. millefolium, T. vulgare) and N125 (E. purpurea). The use of zinc and copper fertilizers in the main application for the studied medicinal crops contributed to an increase in the accumulation of mobile forms of zinc and copper in the medicinal raw materials. On average, over the years of research in experiments with A. millefolium, T. vulgare, E. purpurea, each kg of Zn fertilizers increased the Zn content in plants by 0.30 and 0.38, Cu - by 0.07, 0.05 and 0.03 mg / kg; while 1 kg of fertilizer added by Cu increased the Cu content by 0.47, 0.07 and 0.23, Zn by 1.40, 2.32 and 1.26 mg / kg, respectively. A synergistic relationship has been establish between the elements of Zn↔Cu and Cu↔Zn.

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