1-3% of human population is affected by psoriasis. Nail disorders are reported in 10-80% of patients with psoriasis. Nail deformations vary according to their degree of severity but are mainly represented by pitting, Beau's lines, hyperkeratosis, onycholysis, leuconychia or oil drops. Onychomycosis is a fungal infection of the nails, caused by dermatophytes, yeast and moulds. In this study, 228 patients with psoriasis aged between 18 and 72 were examined (48 - from Plovdiv, Bulgaria; 145 - from Pleven, Bulgaria and 35 - from Thessaloniki, Greece); 145 of them were male and 83 of them were female. The examination of the nail material was performed via direct microscopy with 20% KOH and nail samples plated out on Sabouraud agar methodology. The severity of the nail disorders was determined according to the Nail Psoriasis Severity Index (NAPSI). Positive mycological cultures were obtained from 62% of the patients with psoriasis (52%- Plovdiv, Bulgaria; 70%- Pleven, Bulgaria and 43%- Thessaloniki, Greece). In 67% of the cases, the infection was caused by dermatophytes, in 24% by yeast, in 6% by moulds and in 3% by a combination of causes. All patients with psoriasis were identified with high levels of NAPSI, whereas the ones with isolated Candida had even higher levels. Seventeen percentage of the patients have been treated with methotrexate, 6% have been diagnosed with diabetes and 22% have been reported with onychomycosis and tinea pedis within the family. An increased prevalence of onychomycosis among the patients with psoriasis was found. Dystrophic nails in psoriasis patients are more predisposed to fungal infections. The mycological examination of all psoriasis patients with nail deformations is considered obligatory because of the great number of psoriasis patients diagnosed with onychomycosis.

Summary Onychomycosis is a chronic disease caused by dermatophytes, yeasts and molds, which leads to destruction of the nail plate of the fingernails and toenails. The incidence of onychomycosis in children is considerably smaller compared with that in adults. Onychomycosis in children under 6 years of age is particularly unusual. The trauma and the hyperhidrosis after puberty are the major predisposing factor for fungal nail infection in childhood. Some systemic diseases and congenital syndromes have a crucial role for the development of onychomycosis in children. Wearing infected socks and shoes of other family members, family history for fungal infection of the nails, reduced hygiene and onychophagia are other important predisposing factors. Dermatophytic species Trichophyton rubrum, Trichophyton mentagrophytes and Epidermophyton flocosum are the most frequent causative agents of onychomycosis in adults and much less common yeast of the genus Candida. A retrospective study for a period of 11 years was performed (2003-2013) investigating 292 children aged 0 to 18 years with proven onychomycosis (123 - from Plovdiv, Bulgaria, 94 - from Pleven, Bulgaria, and 75 - from Thessaloniki, Greece). Candida albicans was the main etiologic agent in onychomycosis in children under 18 years of age, according to the performed retrospective study. The diagnose was made by direct microscopic examination and fungal culture on Sabouraud agar media.

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Sneddon's syndrome is usually characterized by the association of an ischemic cerebrovascular disease and a widespread livedo reticularis. The incidence of Sneddon syndrome is 4/1000 000. We present 42-year-old woman with livedo reticularis, recurrence ischaemic cerebrovascular accidents, two repetitive miscarriages and positive anti-2GPi antibodies. Skin biopsy specimens reveal inflammatory changes of small-to medium-sized arteries and subendothelial proliferation and fibrosis. The diagnosis Sneddon syndrome is confirmed by skin biopsy, and MR evidence.We suggest that anti-2GPi antibodies may be pathophysiologically related to the clinical manifestation observed in some patients with Sneddon syndrome.

Introduction: Verruca Plantaris is a dermatovirosis, which occurs with single or multiple papulo-tumorous and papillomothous surfaces on the athletes' feet. Aim: The aim of this study was to determine the prevalence of verruca plantaris in athletes training in fitness more than 5 years Methodology: In our study there were included 70 randomly selected men athletes training in fitness more than 5 years. They were ranged by age from 25 to 30 years. Each of the study participants were examined by a dermatologist. Results: Verruca Plantaris was found in 33 (47 %) of the tested athletes. Results of our study showed that at 10 of the athletes Verruca Plantaris affects only one of the legs and at 23 affects both feet. 72.7 % (n=24) of the athletes were not able to train in fitness for at least 2 weeks during the acute phase of the Verruca Plantaris, which cause a disturbing of athletes' quality of life and distress. Discussion and conclusions: Verruca Plantaris is caused by human papillomavirus and affects the fingers of the lower limbs and/or the feet. Verruca Plantaris could be extremely painful when walking. Verruca Plantaris affects the quality of life of athletes and reduces athletic performance. It is important to make a program for the prevention of the infection of Verruca Plantaris and to be applied in fitness.