Introduction. Recent publications indicate that the most common comorbidities in hospitalized patients with coronavirus infection were arterial hypertension (AH), diabetes mellitus (DM), and coronary heart disease. However, the peculiarities of AH course in post-COVID-19 patients, especially with concomitant DM, are insufficiently covered in the relevant literature. The aim of the study. Тo investigate the peculiarities of hypertension course in patients with concomitant diabetes mellitus previously affected with COVID-19 infection. Materials and methods. We examined 48 patients with essential hypertension of stage II-III of 1-3 degrees, and concomitant DM, previously affected with Covid-19, 52-72 years of age. Results. It has been estimated that more than 1/3 of patients with hypertension who relapsed to COVID-19 complained of frequent headaches, palpitations, coughs, muscle and joint pain, fatigue and sleep disturbances. However, patients with concomitant DM were significantly more likely to complain of general weakness and indigestion. In many patients, regardless of the presence of concomitant pathology, in the postcocious period there was indicated an increase in C-reactive protein more than 3 mg/l and enhanced fibrinogen levels, indicating an increased risk of cardiovascular complications in this group patients. Most patients experienced worsening of blood pressure control during COVID-19 treatment. Uncontrolled hypertension was significantly more common in patients hospitalized for the treatment of acute COVID-19, regardless of DM presence. Conclusions. In patients with AH and concomitant DM significantly more often (76.0 % of cases (p is equal to 0.01)) – compared to patients with AH without DM (60.9 %) was detected uncontrolled hypertension in the post-COVID period. Worsening of blood pressure control in patients with concomitant DM is significantly more common (p value less than 0.001) in those patients who took three or more antihypertensive drugs, this notion require additional correction of antihypertensive therapy.

Cardiac arrhythmias in patients with COVID-19 infection may be due to many pathophysiological factors. Further study on the structure of arrhythmias in this category of patients will reveal clinically significant arrhythmias and select the optimal management. The aim: to determine the features of arrhythmias in patients with and without concomitant cardiovascular disease who suffered from COVID-19 infection based on the results of 24-hour electrocardiogram (ECG) monitoring. Materials and methods. 84 patients (45 men – 53.5 %, 39 women – 46.5 %) who had COVID-19 infection over 12 weeks previously were examined. Patients were divided into 2 groups – with and without a history of concomitant cardiovascular disease. The patient groups did not differ in age (P = 0.33) and sex (P = 0.58, P = 0.64). 24-hour ECG monitoring was performed on a Cardiosens K device (XAI-MEDICA, Kharkiv) according to the standard method. Results. Comparison of 12-channel ECG data did not reveal a significant difference in the incidence of single atrial (P = 0.13) and ventricular extrasystoles (P = 0.37) between the two groups, but sinus tachycardia was significantly more common in patients without concomitant cardiovascular disease (P = 0.022). According to 24-hour ECG monitoring, a significantly higher total number of arrhythmias, in particular, supraventricular extrasystoles (P = 0.009), high gradations of ventricular arrhythmias: paired ventricular extrasystoles (P = 0.041), ventricular bigeminy (P = 0.005), ventricular trigeminy (P = 0.004), ventricular salvos (P = 0.017) were detected significantly more frequently in patients with concomitant cardiovascular disease after COVID-19 infection than those in the comparison group. The results of 24-hour ECG monitoring also showed that patients without cardiovascular disease were significantly more likely to have inappropriate sinus tachycardia (P = 0.03) and postural orthostatic tachycardia (P = 0.04). Paroxysmal arrhythmias were significantly more common in patients with concomitant cardiovascular pathology, namely unstable (P = 0.002) and stable paroxysms of atrial tachycardia (P = 0.014), unstable paroxysms of monomorphic ventricular tachycardia (8.3 %), paroxysms of atrial fibrillation (6.2 %). Conclusions. 24-hour ECG monitoring should be advised in patients with COVID-19 infection and concomitant cardiovascular disease in addition to recording a standard 12-channel ECG to detect prognostically unfavorable cardiac arrhythmias, possible arrhythmogenic manifestations of post-COVID-19 syndrome and choose management tactics for these patients.

Introduction. Arterial hypertension is the most common risk factor of cardio-vascular complications, while most objectively controlled by physician [3]. According to different studies, the effective control of blood pressure le vel in the population of patients with elevated blood pressure is not achieved [4]. It should be recognized that in majority of patients with hypertension, the prescribed treatment is ineffective. Clearly, this situation is the cause for concern and requires the measures for the improvement.The prevalence of arterial hypertension in Ukraine reaches 35.0 % among the adult population [1]. The frequency of cases of resistant hypertension in the population of patients with hypertension varies from 5.0 to 18.0 % [7], however, there is no single view of its true prevalence. The number of these patients varies considerably depending on the place of the study [6]. Resistant hypertension occurs in 5.0-10.0 % of patients with hypertension in primary care practice, and in 25.0-30.0 % of hospitalized patients with hypertension [5]. However, the true prevalence of resistant hypertension is difficult to quantify because many patients actually suffer from pseudoresistant hypertension, the main reasons of which are the lack of adherence to treatment and ineffective antihypertensive therapy (the choice of ineffective drugs, their insufficient number, the use of them in small doses etc.) [9]. In the structure of resistant arterial hypertension, pseudoresistant is observed in 90.0-95.0 % of cases [8].Existing general guidelines for the treatment of arterial hypertension do not provide doctors with a clear plan of selecting antihypertensive drugs and individualization of therapy in each particular case [1,7]. At the same time, in patients with pseudoresistant arterial hypertension, antihypertensive drugs effectively control the blood pressure, compared to patients with the resistant arterial hypertension [6]. In this regard, it is relevant to work out the methods of differential diagnosis of essential resistant

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