The need for additive manufacturing (3D printing) to create near net shape components from a wide variety of materials has grown in recent years. There are several additive manufacturing methods to build various parts by different materials. However, it is challenging to construct, the components with incompatible materials combination for high temperature and creep resistance using conventional methods. Consequently, the purpose of this research is to investigate the use of solid state welding (friction welding) in additive manufacturing (SSAM) of incompatible materials, namely alloy Cr18-Ni8 and 42CrMo4 low alloy alternative layers. The interface bonding strength must be strengthened to achieve the desired isotropic characteristics and high strength for the components. Due to the low temperature at the bonding interface, secondary phases cannot develop when solid state welding is used. In order to obtain the highest bonding strength, optimal process parameters were examined using design of experiments (DOE) with Box–Behnken design model and analysis of variance (ANOVA). The major process parameters of upset pressure, friction pressure and burn-off length were varied to obtain the optimal conditions. In addition, the bonded interfaces were examined by the microstructural characteristics as well as mechanical properties such as micro-hardness and bonding strength. The interface is made up of alloys intermixed with different zones such as a dynamically recrystallized zone and a thermomechanical affected zone. The intermixed layers revealed the migration of C and Mo to Cr18-Ni8 alloy and separated the Fe and Ni bands. The fractography analysis revealed ductile and slightly brittle fracture surfaces with a mixed mode. The relationship between bond strength and interface thickness was determined by studying the impact of interface thickness on bond strength.