No abstract

Background/objective: The aim of the study is to synthesize derivatives of colchicine, which is an anti-gout drug, and to enhance the antimicrobial activity of it. As it is observed in case study of drugdrug interaction, i.e. Colchicine and clarithromycin, which is known as antimicrobial drug has given fatal results, in consequence to that we have tried to enhance the antimicrobial activity of the drug itself, as there is always a need of antimicrobial drugs in the treatment of gout. In addition, to study the binding of protein and colchicine through molecular docking. Methods/analysis: In this work, the detailed molecular docking study of colchicine has been done and complexes of colchicine with Co (II), Ti(II), Ni (II) Fe (II) Zn(II) Cu(II) are synthesized and investigated by using IR, and antimicrobial antifungal screening. Findings/application: Docking shows the exact binding site of the ligand which is beta-tubulin inhibitor. It is also observed that first transition series metal forms stable complexes with this ligand specially and shows enhanced antimicrobial activity.

Colchicine is essentially useful in the treatment of gout. In the present work Colchicine Complexes has been prepared with transition metals viz; Copper(II) [Cu(II)], Zinc (II) [Zn(II)], Cobalt (II) [Co(II)], Nickel (II) [Ni(II)] and those checked for molecular docking, it has been observed that Zn(II) and Ni(II) complex has revealed good binding energy than the parent ligand, the increased binding energy of colchicine metal complexes  indicates that, the tubulin polymerization inhibitor tendency is enhanced, consequently antigout property is also increased. As transition metals have antimicrobial activity in themselves, complexes are also characterized for the antimicrobial activity which is enhanced for Cu(II) and Co(II) metals.