In recent years, many studies were published describing a wide scope of changes related to extreme (stormy) geomagnetic activity. In some countries, prediction of such days is a part of weather prediction information. A number of risk factors like blood coagulation parameters, arterial blood pressure, inflammation markers, and some blood proteins were changing at days of GMA storms. Concomitant studies were published on an inverse phenomenon-increased cardiovascular event at days of Zero GMA, accompanied by high Space Neutron activity on the Earth's surface-a marker of high Cosmic Ray activity. The aim of this study was to compare two groups of Acute Cardiovascular Events (ACE)-Acute Myocardial Infarction (AMI) and deaths from Ischemic Heart Disease (IHD) at days of extreme Cosmic Ray (CRA)-Neutron activity. Patients & methods: 4749 days at years 2000-2012 were studied considering ACE in a 3000 bed hospital in Kaunas, Lithuania. Cosmophysical data of this period was obtained from USA, Russia, and Finland. ACE was calculated at day of extreme High levels of CRA and following 48 hours. 13629 AMI and 3128 deaths from IHD were included. Results: It was a significant rise in AMI morbidity at day of high CRA (Neutron) activity (≥9300 imp/min). By analysis for each of gender, and patients age groups that were significant difference of AMI for all patients and male >65 y. old at Neutron activity ≥9400 imp/min (p = 0.048; p = 0.03), both gender > 65 y. old at Neutron activity >9500 (p = 0.078) and female >65 y. at Lag 2 (p = 0.07). For deaths from IHD, it was a significant rise at Neutron activity below 9300 * In memory of our Coauthor and Colleague Professor Stanislava Domarkiene. E. Stoupel et al. 403 imp/min (662 days (13.8%) were above the average of the full observation time-8935 ± 538.083)). Conclusion: At days of high CRA-Neutron activity, it was significantly more AMI. For IHD mortality was higher, but at lower Neutron activity-closer to average Neutron activity and higher GMA.