The present investigation was aimed to prepare inclusion complexes of a therapeutically important nonsteroidal anti-inflammatory drug, etodolac (ETD) with hydroxypropyl-beta-cyclodextrin (HP-β-CD) and to study the effect of l-arginine (l-Arg) as an auxiliary agent on the complexation efficiency of HP-β-CD to improve aqueous solubility and the dissolution property of ETD. The binary and ternary complexes were prepared by physical mixing, coevaporation, and spray drying methods. The complexes were characterized using differential scanning colorimetry (DSC), Fourier transform-infrared spectroscopy (FT-IR), and powder X-ray diffraction (PXRD) studies. The mechanism of inclusion interaction of guest and host was established through H NMR, molecular docking, and molecular dynamics studies. On the basis of preliminary screening studies, l-Arg was found to be the most efficient auxiliary agent for the present research problem. The change in crystallinity of ETD was evident from DSC and PXRD studies which indicated the formation of new solid forms. A remarkable increase in apparent stability constant (K) and complexation efficiency (CE) of HP-β-CD was observed in the presence of l-Arg in ternary complexes with improvement in solubility and dissolution of ETD than binary complexes. However, inclusion complexes of ETD obtained by computational studies is in good correlation with the results obtained through experimental methods. More stable complex formation with l-Arg was confirmed by molecular simulation studies too. Thus, the present study led to the conclusion that the ternary complex of ETD-HP-β-CD-l-Arg could be an innovative approach to augment the solubility and dissolution behavior of ETD.

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Dengue is one of the most emerging viral diseases globally and it is classified as a major global health threat by world health organization (WHO).It is mosquito-borne viral infection caused by Flavivirus and transmitted by vector Aedes Aegypti. It is acute, infectious and self-limiting illness which has variable clinical manifestations ranging from asymptomatic to shock or death. Cardiac involvement is not uncommon in dengue, still in majority cases it remain underdiagnosed which further contributes to serious complications and sometimes leading to mortality Aim and Objectives1. To study the correlation between Dengue fever and its effect on Cardiac function through ECG changes. 2. To find conclusive evidence of correlation between ECG and dengue associated cardiac dysfunction Methods: Patients admitted in our hospital with diagnosed Dengue will be enrolled. Patients will be evaluated on the basis of: History of illness  Clinical examination  Relevant investigations  Treatment given  Response to treatment Conclusion: Cardiac involvement is not uncommon in dengue ,still in majority cases it remain underdiagnosed which further contributes to serious complications and sometimes leading to mortality. The exact mechanism of involvement of heart in dengue remains unclear. Presence of myocarditis in dengue patients is not always significant but it should alert the treating clinicians that such patients may require regular and continuous monitoring. It is necessary to create awareness and knowledge of cardiac complication of dengue fever between clinicians and patients, which will help us in early recognition and prompt treatment.