The effects of feeding imidacloprid were assessed in the liver of Japanese quails and studied the effect of feed mix of Butea monosperma on ameliorating effect against the imidacloprid toxicity. The serum biochemical assay revealed significant increase in AST, ALT and GGT in imidacloprid treated birds. Histologically, the liver showed sinusoidal dilatation, bile duct hyperplasia and periportal necrosis. Ultra thin sections of liver revealed numerous fat globules, condensed hepatocytes and mitochondria with granular cytoplasm. It was observed that co-treatment with Butea monosperma moderately restored the imidacloprid induced changes.