Sinonasal glomangiopericytoma is defined as a low-grade malignant tumor demonstrating a perivascular myoid phenotype. We report a case of sinonasal glomangiopericytoma having a diffuse architecture with bland spindle cells arranged in short fascicles, storiform, whorled, reticular pattern, separated by a vascular plexus ranging from capillaries to large patulous spaces. Immunohistochemistry is required to differentiate it from other perivascular tumours and solitary fibrous tumour. However, differentiating glomangiopericytomas and solitary fibrous tumours based on immunohistochemistry is a challenge. The tumour expressed vimentin, focal smooth muscle actin and CD34, diffuse, strong Bcl2 and Beta catenin and negative STAT6. Immunohistochemical expression of STAT6 is useful as a negative marker in the diagnosis and separation of glomangiopericytoma from solitary fibrous tumour. Key Messages: Sinonasal glomangiopericytoma (SNGP), a rare tumour with low malignant potential as per WHO classification is frequently confused with sinonasal solitary fibrous tumour (SFT). This article emphasizes the importance of using a broader immunohistochemical panel of positive and negative markers for differentiating SNGP from SFT. The most useful among them being CD34, SMA, BCL2, Beta Catenin and STAT6.
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