The comorbidity between hypertension with diabetes leads to an increase in the risk of death and cardiovascular events by 44% and 41%, respectively, compared with 7% and 9% risks in people suffering only from diabetes and having no hypertension. Purpose. To determine the effect of the criteria for the diagnosis of hypertension proposed by ACC/AHA (2017) and ESC/ESH (2018) on the detection of this disease in people with normal carbohydrate metabolism, prediabetes and type 2 diabetes mellitus. Materials and methods. A retrospective analysis of the database of the Azerbaijan Association of Endocrinology, Diabetology and Therapeutic Training was carried out. The data of 596 examined patients were analyzed, then three main groups were formed: a group with normal carbohydrate metabolism (n=99), a group with prediabetes (n=47), a group with type 2 diabetes mellitus (n = 450). The patients included in the study were divided into 2 samples: those, who have DM2; those, who have no DM2. Including the patients in the group of with DM2 was based medical history data about the presence of DM2 and / or taking hypoglycemic drugs. Results. When applying the ACC/AHA criteria (2017), normotension (systolic blood pressure <130 mmHg and diastolic blood pressure <80 mmHg) occurred in 40.4% (95% CI 30.69%; 50.12) of the control group, while 59.6% (95% CI 49.88; 69.31) there was arterial hypertension. 14.9% of the prediabetes group (95% CI 4.60%; 25.18)% had normotension according to the same criteria, while the majority of the participants in this group – 85.1 (95% CI 74.82; 95.40)% had arterial hypertension. In the type 2 diabetes mellitus group, normotension was found in 15.8 (95% CI 12.41%; 19.15)%, and arterial hypertension – in 84.2 (95% CI 80.85; 87.59)%. Thus, arterial hypertension was statistically significantly less common in the control group than in prediabetes (p <0.01) and type 2 diabetes mellitus (p <0.001). Conclusion. Thus, in people with normal carbohydrate metabolism, prediabetes and type 2 diabetes mellitus, the use of ACC/AHA diagnostic criteria (2017) led to a statistically significantly higher incidence of hypertension than when using the criteria for the diagnosis of hypertension according to ESC/ESH (2018).

Unification of the approach to the diagnosis of prediabetes (PD) is hardly in doubt. The borderline between PD and diabetes is recognized by all, as well as the upper and lower bounds of PD according to the results of glycemia 120 minutes after 75 g glucose loading (GL120). There are still ambiguities regarding glycohemoglobin (HbA1c) and fasting glycemia (FG). For determination of the Norma/PD cut-off point for FG, we analyzed 85 nondiabetic glucose tolerance test results (75.0 glucose; Samples of fasting blood, and 30, 60, 90, 120 minutes after glucose loading) by using correlation and regression analysis. Glycemic values were measured in mg/dl, HbA1c values were measured in %. The fact of identifying the relationship between FG and Gl120 (r=+0.52 [95%CI +0.346, +0.659]; p&lt;0.001), as well as between FG and HbA1c (r=+0.59 [95%CI +0.432, +0.713]; p&lt;0.001) were the basis of this study. As a result of using regression analysis, multiple regression equations were obtained. GL0 =-4.2439 + 0.1927 * GL120 + 15.462 * HbA1c If GL120 is equal to 139 mg/dl (in accordance with all recommendations), and HbA1c is equal to 5.9% (in accordance with the recommendations of NICE, Canadian Diabetes Association, Australian Diabetes Association, et al.), the maximal normal value for FG should be equal to 114 mg/dl. If GL120 is 139 mg/dl and HbA1c is 5.6% (as recommended by the American Diabetes Association), the maximum normal value of FG should be 109 mg/dl. The optimal upper limit of normal carbohydrate metabolism is levels of GL120 equal to 139 mg/dl, HbA1c - equal to 5.6%, and FG - equal to 109 mg/dl. Values above these and below diabetic levels (200 mg/dl, 6.5%, and 126 mg/dl, respectively) can be considered as prediabetes.

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Aim. To evaluate effects of metabolic disorders on the risk of cardiovascular death in patients with type II diabetes based on Framingham risk score. We analyzed results of examination of 210 men and 210 women with type 2 diabetes who applied for medical care to the VM center of Endocrinology during 1997-2014. A virtual control group was formed matching real patients in terms of the number, sex, age, and height having ideal body mass index, total cholesterol and high-density lipoprotein cholesterol levels. The average risk of cardiovascular death in patients with type 2 diabetes was equal to 4,56±0,254% compared with 0,6±1,028% in the virtual control group. The differences was significant (p <0,001). The minimum risk for the patients of the two groups was estimated at 0,001% and 0,01% respectively. The maximum risk of cardiovascular death is 34,17% in patients with diabetes and 8,24% in controls. It is concluded that type 2 diabetes and related metabolic disorders significantly increase the risk of cardiovascular death.

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