The dynamical balance on the Amazon shelf and its implication on the properties of the Amazon River plume is not fully understood and poorly represented in global‐ and basin‐scale ocean models. In this study, the sensitivity of the Amazon shelf dynamics to tidal forcing is explored with a set of high‐resolution numerical simulations (1/36°) with and without the tide. A comparison of the simulations with sea surface salinity in situ measurements at 5°N (a location where the plume seasonally detaches from the coast and retroflects toward the east) revealed that the explicit resolution of the tide significantly improves the representation of the offshore spread of the river plume. This study further highlights the finding that tidal currents affect the properties of the whole Amazon plume. This sensitivity is explained by a near total collapse of the northwestward alongshore mean flow located near the river mouth, once the tidal forcing is included. This weakening of the ambient flow reduces (i) the dilution ratio between the ambient salty shelf waters and the riverine freshwaters and (ii) the constraint on the cross‐shore extension of the low‐salinity bulge. With tides, the plume is fresher near the river mouth (by up to 5 units), more extended in the cross‐shore direction, and more easily exported offshore by the North Brazil Current at the shelf break.

Kabuki syndrome (KS, KS1: OMIM 147920 and KS2: OMIM 300867) is caused by pathogenic variations in KMT2D or KDM6A. KS is characterized by multiple congenital anomalies and neurodevelopmental disorders. Growth restriction is frequently reported. Here we aimed to create specific growth charts for individuals with KS1, identify parameters used for size prognosis and investigate the impact of growth hormone therapy on adult height. Growth parameters and parental size were obtained for 95 KS1 individuals (41 females). Growth charts for height, weight, body mass index (BMI) and occipitofrontal circumference were generated in standard deviation values for the first time in KS1. Statural growth of KS1 individuals was compared to parental target size. According to the charts, height, weight, BMI, and occipitofrontal circumference were lower for KS1 individuals than the normative French population. For males and females, the mean growth of KS1 individuals was −2 and −1.8 SD of their parental target size, respectively. Growth hormone therapy did not increase size beyond the predicted size. This study, from the largest cohort available, proposes growth charts for widespread use in the management of KS1, especially for size prognosis and screening of other diseases responsible for growth impairment beyond a calculated specific target size.