Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) [odds ratio (OR) = 1.09, P = 1.9 × 10(-9)] and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 × 10(-9)).

Subduction zones are pivotal for the recycling of Earth’s outer layer into its interior. However, the conditions under which new subduction zones initiate are enigmatic. Here, we constructed a transdisciplinary database featuring detailed analysis of more than a dozen documented subduction zone initiation events from the last hundred million years. Our initial findings reveal that horizontally forced subduction zone initiation is dominant over the last 100 Ma, and that most initiation events are proximal to pre-existing subduction zones. The SZI Database is expandable to facilitate access to the most current understanding of subduction zone initiation as research progresses, providing a community platform that establishes a common language to sharpen discussion across the Earth Science community.

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Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association (GWA) study, meta-analysis and follow-up (totaling as many as 18,206 cases and 42,536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7,469 bipolar disorder cases, 1,535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46,160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T], OR = 1.08, P = 6.6 × 10−11). The new variant is located within a 593 kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P = 0.0039 in the public GIANT consortium dataset; P = 0.00047 in 22,651 additional Icelanders).

We investigate the dehydration processes in subduction zones and their implications for the water cycle throughout Earth's history. We use a numerical tool that combines thermo-mechanical models with a thermodynamic database to examine slab dehydration for present-day and early Earth settings and its consequences for the deep water recycling. We investigate the reactions responsible for releasing water from the crust and the hydrated lithospheric mantle and how they change with subduction velocity (vs), slab age (a) and mantle temperature (Tm). Our results show that faster slabs dehydrate over a wide area: they start dehydrating shallower and they carry water deeper into the mantle. We parameterize the amount of water that can be carried deep into the mantle, W (×105 kg/m2), as a function of vs (cm/yr), a (Myrs), and Tm (°C):. We generally observe that a 1) 100°C increase in the mantle temperature, or 2) ∼15 Myr decrease of plate age, or 3) decrease in subduction velocity of ∼2 cm/yr all have the same effect on the amount of water retained in the slab at depth, corresponding to a decrease of ∼2.2×105 kg/m2 of H2O. We estimate that for present-day conditions ∼26% of the global influx water, or 7×108 Tg/Myr of H2O, is recycled into the mantle. Using a realistic distribution of subduction parameters, we illustrate that deep water recycling might still be possible in early Earth conditions, although its efficiency would generally decrease. Indeed, 0.5–3.7 × 108 Tg/Myr of H2O could still be recycled in the mantle at 2.8 Ga.Key PointsDeep water recycling might be possible even in early Earth conditions We provide a scaling law to estimate the amount of H2O flux deep into the mantle Subduction velocity has a a major control on the crustal dehydration pattern