In this Minireview we outline the development of cyclic aliphatic moieties as ligands in metal-organic frameworks (MOFs), with a focus on the relationship between ligand design and synthesis and the properties of the subsequent materials. Aliphatic ligands have received considerably less attention than aromatic analogues in MOF chemistry but offer advantages in their unique combinations of geometric and electronic proper-ties which are unattainable from conventional ligands. Here, we focus on rigid and semi-rigid backbone moieties derived from monocyclic and fused polycyclic aliphatic backbones, including cyclohexane and adamantane, cubane and bicyclo[2.2.2]octane, and discuss the synthetic chemistry of these species along with their potential importance as the next generation of building blocks for microporous materials.[a] V. . The synthesis of bicyclo[2.2.2]octane-1,4-dicarboxylic acid reported by Li and co-workers, and its coordination chemistry in the presence of cobalt(II) ions. [72] Hydrogen atoms are omitted for clarity. Reagents and conditions: (i) NaH, DME, reflux, then 1,2-dibromoethane, reflux; (ii) 1,2ethanedithiol, BF 3 ·Et 2 O, 0°C -RT; (iii) Raney-Ni, EtOH, reflux; (iv) NaOH, EtOH/ H 2 O, reflux, then HCl. ChemPlusChemMinireviews

Analogues of the canonical nucleosides have a longstanding presence and proven capability within medicinal chemistry and drug discovery research. The synthesis reported herein successfully replaces furanose oxygen with CF2 and...

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The first of a new class of spiroalkane-derived MOF linkers shows aromaticity is not a prerequisite for ligand design in porous materials.

Three compounds consisting of pyridinium or morpholinium hydrogen oxalates each display different hydrogen oxalate hydrogen-bonding motifs, resulting in chains for 4-(di­methyl­amino)­pyridinium hydrogen oxalate 0.22-hydrate, dimers for 4-tert-butyl­pyridinium hydrogen oxalate and chains for morpholinium hydrogen oxalate.