To retrospectively assess the effectiveness and safety of customized hemostatic protocols using a plasmaderived, von Willebrand Factor (VWF)-containing Factor VIII concentrate (pdVWF/FVIII) in von Willebrand disease (VWD) patients undergoing dental invasive procedures. Methods: Protocol for each patient was drawn up by the Blood Unit based on the VWD type, disease severity, and type of treatment. pdFVIII/VWF infusions and doses were registered at 30-60 min before intervention (t0) and at 12-24-36-48-72 h after intervention (t12-t72) and up to day 7. Any peri-or postoperative bleeding, complication or adverse event was registered. Results: Forty-five dental procedures were performed on 20 VWD patients (six type-1, two type-2a, six type-2b, six type-3). Most pdFVIII/VWF infusions at t0 were 60 IU/kg (n ¼ 7) and 50 IU/kg (n ¼ 9). Subsequent infusions were mostly 30-50 IU/kg. No bleeding complications or adverse events were reported. Conclusion:This study supports the safety and efficacy of pdFVIII/VWF to prevent peri-and postoperative bleeding after invasive oral procedures.