Objective: This study examines the effects of having a tobaccofree policy in three University of Alaska campuses two years postimplementation among students, faculty, and staff. It also identifies factors associated with tobacco cessation and ENDS use. Methods: Self-administered online survey was conducted in spring 2017 and 2018.Results: Most of the current tobacco users began using tobacco prior to policy implementation, while most current ENDS users in 2018 started using ENDS when the policy had been in place. Students and those who are younger are more likely to quit tobacco during policy implementation; and males, students, and those who are younger and current tobacco users are more likely to use ENDS.Conclusions: Study findings suggest that campus tobacco-free policy can promote tobacco cessation and help prevent tobacco initiation. However, such a policy does not necessarily affect ENDS use. Specific groups need additional interventions to assist in tobacco and ENDS cessation.