A randomized controlled phase I/II clinical trial was designed to evaluate the safety and efficacy of encapsulated human umbilical cord mesenchymal stem cells in a plasma-derived biomaterial for regenerative endodontic procedures (REPs) in mature permanent teeth with apical lesions. The trial included 36 patients with mature incisors, canines, or mandibular premolars showing pulp necrosis and apical periodontitis. Patients were randomly and equally allocated between experimental (REP) or conventional root canal treatment (ENDO) groups. On the first visit, cavity access and mechanical preparation of the root canal were performed. Calcium hydroxide medication was used, and the cavity was sealed. Three weeks later, patients were treated following their assigned protocol of ENDO or REP. Clinical follow-up examinations were performed at 6 and 12 mo. Categorical variables were evaluated by Fisher’s exact test. Quantitative variables were compared using the Mann-Whitney test. The evolution over time of the percentage of perfusion units and the dimensions of lesion and cortical compromise were explored. After the 12-mo follow-up, no adverse events were reported, and the patients showed 100% clinical efficacy in both groups. Interestingly, in the REP group, the perfusion unit percentage measured by laser Doppler flowmetry revealed an increase from 60.6% to 78.1% between baseline and 12-mo follow-up. Sensitivity tests revealed an increase of the positive pulp response in the REP group at 12-mo follow-up (from 6% to 56% on the cold test, from 0% to 28% on the hot test, and from 17% to 50% on the electrical test). We present the first clinical safety and efficacy evidence of the endodontic use of allogenic umbilical cord mesenchymal stem cells encapsulated in a plasma-derived biomaterial. The innovative approach, based on biological principles that promote dentin-pulp regeneration, presents a promising alternative for the treatment of periapical pathology (ClinicalTrials.gov NCT03102879).

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In the present study, pregnant women with periodontal disease presented an association in the placental tissue between the presence of T. denticola and P. gingivalis and hypertensive disorders. Additionally, increased expression of TLR-2 was observed. However, further studies are required to determine the specific roles of periodontal pathogens and TLRs in the placental tissue of patients with pregnancy-related hypertensive disorders.

Se presentan los resultados iniciales del trabajo de adaptación y estandarización del WISC-III a la población chilena en base a la muestra de estandarización de 1924 niños obtenidos por medio de un muestreo aleatorio estratificado por regiones. Se presentan las principales diferencias con el WISC-R, la estructura factorial y consistencia interna de las escalas del WISC-III. Los resultados del estudio muestran una alta coincidencia con los de la prueba original norteamericana, obteniéndose cuatro factores de inteligencia y consistencias internas adecuadas a este tipo de pruebas. Sin embargo, las subpruebas incluidas en los factores difieren levemente de los resultados de la estandarización nortemericana. Palabras Clave: WISC-III, estandarización de instrumentos.We present the results of the chilean adaptation and standarization of WISC-III. The sample for the study consisted in 1924 children obtained from a ramdomized stratified sampling considering the regions of Chile. Results show a great coincidence with those obtained in the original north-american sample: we obtained the same four intelligence factors and high internal consistencies. Nevertheless, the subscales included in the factors differ slightly from the north-american results.