The Francigena Way (Via Francigena) is a long international itinerary that was awarded recognition as a Culture Route of the Council of Europe. It starts in Canterbury (UK), touches 13 European regions and ends in Rome. An ancient track of this route is in Sicily (Southern Italy), and its name is Magna Via Francigena (Great Francigena Way). This track is a pilgrimage route that connects two ancient port cities, Palermo and Agrigento, passing through internal rural territories that now deal with the exodus of population from rural to urban areas. The route passes through the Sicilian territory named “Upper-Belìce corleonese”, a rural area around the city of Corleone (a little village known worldwide for the sad Mafia events) that includes a number of municipalities. In the past, this religious pilgrimage was a fundamental part of the expression of faith for Christians and now still represents for Sicilians a strong symbol of Christian identity. In recent decades, pilgrimage tourism around the world has grown significantly each year. The aim of the study is to know the pilgrims’ motivations for choosing the Magna Via Francigena pilgrimage as a vacation and any possible similarities between pilgrimage tourism and food and wine tourism, in the wider context of sustainable and slow tourism. The Policy Delphi method was applied to collect the opinions of the stakeholders involved. The study highlighted the strong link between religious motivations and local enogastronomy, culture, art and nature. Results will support policy-making in the development of integrated territorial tourist marketing strategies.

Cutaneous involvement characterized by urticarial lesions with or without angioedema and itch is commonly observed in routine medical practice. The clinical approach may still remain complex in real life, because several diseases may display similar cutaneous manifestations. Urticaria is a common disease, characterized by the sudden appearance of wheals, with/without angioedema. The term Chronic Urticaria (CU) encompasses a group of conditions with different underlying causes and different mechanisms, but sharing the clinical picture of recurring wheals and/or angioedema for at least 6 weeks. Hereditary Angioedema (HAE) is a rare disorder characterized by recurrent episodes of non-pruritic, non-pitting, subcutaneous or submucosal edema affecting the extremities, face, throat, trunk, genitalia, or bowel, that are referred as “attacks”. HAE is an autosomal dominant disease caused by a deficiency of functional C1 inhibitor, due to a mutation in C1-INH gene (serping 1 gene) characterized by the clonal proliferation of mast cells, leading to their accumulation, and possibly mediator release, in one or more organs. In childhood there are two main forms of mastocytosis, the Systemic and the Cutaneous. The clinical features of skin lesions in urticaria, angioedema and mastocytosis may differ depending on the aetiologic factors, and the underlying pathophysiological mechanisms. The diagnostic process, as stepwise approach in routine clinical practice, is here reviewed for CU, HAE and mastocytosis, resulting in an integrated method for improved management of these cutaneous diseases. Taking into account that usually these conditions have also a relevant impact on the quality of life of children, affecting social activities and behavior, the availability of care pathways could be helpful in disentangle the diagnostic issue achieving the most cost-effective ratio.

Interstitial deletions of the long arm of chromosome 14 are relatively rare. We report a 8.5-year-old girl with dysmorphic facial features and mental retardation associated with a de novo interstitial deletion of chromosome 14. The comparison between our patient and all published patients is reviewed. The genetic investigations have allowed us to define the critical chromosomal region and to start an accurate follow-up.

This paper focuses on the potential of the rural landscape of Sicily, the largest island in the Mediterranean Sea, taking into particular account the critical need to deal with the problem of depopulation of the small inner areas by leveraging the "integrated exploitation" of local resources. The rural landscape is considered to be capable of playing an essential role in many fields: ecology, production, culture and tourism. In this regard, guidelines are set by the Sustainable Development Goals of the United Nations, the EU guidelines and the experience from Italy's Rural Development Plans, the latter of which aim at achieving the much sought-after multi-functionality of agriculture. This study has been conducted in our particular moment in history, when new attention is being drawn to the potential of rural landscape due to its fragility, the crisis of traditional production systems and the changes caused by urbanization, which have had irreversible effects on many rural areas, based on traditional agriculture, and on ecosystem services. Keeping this goal in mind, the Sicilian case study should be considered as a sort of "test bench" where the validity of the abovementioned considerations can be tested. The area Agrigento-Caltanissetta-Enna in mid-southeastern Sicily is an area composed of sixteen municipalities in the three (ex) regional provinces of Agrigento, Caltanissetta and Enna, which, from the coast facing Africa (characterised by major cultural sites UNESCO Heritage) stretches to the "heart" of inner Sicily along the "grey line" composed of trunk road S.S. 122. The rural landscape that characterizes this area is the result of a complex process of interactions between various natural and anthropic factors that often conflict with each other and define the identity of the landscape itself and its dynamic and economic processes. The area treated in this paper has been analyzed to highlight its particular features, thus proposing a

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