A 13-year-old spayed female, American Cocker Spaniel, was presented to the referring veterinarian for evaluation of a cough and weight loss. Physical examination findings included a heart murmur, generalized lymphadenopathy, and severe dental disease. Thoracic radiographs revealed cardiomegaly with a soft tissue opacity dorsal to the heart (suspected to be an enlarged peri-hilar lymph node). Ethylenediaminetetraacetic acid (EDTA)-anticoagulated blood,
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