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Evaluate the quantitative, subjective (Deauville score [DS]) and reader agreement differences between standard ordered subset expectation maximization (OSEM) and Bayesian penalized likelihood (BPL) positron emission tomography (PET) reconstruction methods. A retrospective review of 104 F-18 fluorodeoxyglucose PET/computed tomography (CT) exams among 52 patients with diffuse large B-cell lymphoma. An unblinded radiologist moderator reviewed both BPL and OSEM PET/CT exams. Four blinded radiologists then reviewed the annotated cases to provide a visual DS for each annotated lesion. Significant ( P < .001) differences in BPL and OSEM PET methods were identified with greater standard uptake value (SUV) maximum and SUV mean for BPL. The DS was altered in 25% of cases when BPL and OSEM were reviewed by the same radiologist. Interobserver DS agreement was higher for OSEM (>1 cm lesion = 0.89 and ≤1 cm lesion = 0.84) compared to BPL (>1 cm lesion = 0.85 and ≤1 cm lesion = 0.81). Among the 4 readers, average intraobserver visual DS agreement between OSEM and BPL was 0.67 for lesions >1cm and 0.4 for lesions ≤1 cm. F-18 Fluorodeoxyglucose PET/CT of diffuse large B-cell lymphoma reconstructed with BPL has higher SUV values, altered DSs and reader agreement when compared to OSEM. This report finds volumetric PET measurements such as metabolic tumor volume to be similar between BPL and OSEM PET reconstructions. Efforts such as adoption of European Association Research Ltd accreditation should be made to harmonize PET data with an aim at balancing the need for harmonization and sensitivity for lesion detection.

Purpose: Various prognostic indices (PIs) have been described for patients undergoing endovascular interventions for Budd-Chiari syndrome to predict mortality and clinical success. This study aimed to evaluate role of the BCS PIs to predict mortality and clinical success. Materials: This retrospective study enrolled 100 patients with primary BCS who underwent endovascular interventions at Asian Institute of Gastroenterology, Hyderabad from Jan 2007 to Dec 2016. Child-Pugh-Turcotte score (CPT), model for end stage liver disease score (MELD), Original Clichy, New Clichy and Rotterdam score were calculated. The overall mortality and clinical success after endovascular interventions were collected. Clinical success was defined as alleviation of symptoms with establishment of adequate blood flow across obstruction. Clinical failure was defined as persistence of symptoms or continuous need for diuretic therapy at the end of 1 month. Results: A total of 100 patients were analyzed with mean median follow-up of 20 (6-105) months. Overall mortality was 6% and clinical failure was noted in 17% patients. The overall mortality was best predicted by CTP score at cutoff value of 9, with sensitivity 64.89% (95%CI 54.36 to 74.46%) and specificity 83.33% (95%CI35.88 to 99.58%) with AUC 0.78 followed by MELD score at cutoff value of 16, with sensitivity 68.09% (95% CI 57.67 to 77.33) and specificity 83.33% (95% CI 35.88 to 99.58%) with AUC 0.71. The clinical failure was predicted by Rotterdam score (AUC 0.72), CTP (AUC 0.68), MELD (AUC 0.658) and New Clichy (AUC 0.6524). Conclusions: Advanced CTP score and MELD can predict mortality in BCS. Rotterdam score can predict need for re-intervention in BCS. BCS PIs are useful in clinical algorithm in the management of BCS.