Network coding (NC) is considered a breakthrough to improve throughput, robustness, and security of wireless networks. Although the theoretical aspects of NC have been extensively investigated, there have been only few experiments with pure NC schematics. This paper presents an implementation of NC in a two-way relay model and extend it to two nonstraightforward scenarios: i) multimedia transmission with layered coding and multiple-description coding; ii) cognitive radio with Vandermode Frequency Division Multiplexing (VFDM). The implementation is in real time and based on Software-Define Radio (SDR). The experimental results show that, by combining NC and source coding, we can control the quality of received multimedia content in an on-demand manner. Whereas in the VFDM-based cognitive radio, the received content in the primary receive is low quality (due to imperfect channel estimation) yet retrievable. Our implementation results serve as a proof for the practical feasibility of network coding in relevant applications.