We report for the first time the preparation of luminescent lanthanide nanomaterial (LLN) linked bioconjugates and their application as a label tool for recognizing virus in the processing line of vaccine industrial fabrication. Several LLNs with the nanostructure forms of particles or rods/wires with europium (III) and terbium (III) ions in lattices of vanadate, phosphate and metal organic complex were prepared to develop novel fluorescent conjugates able to be applied as labels in fluorescence immunoassay analysis of virus/vaccine.With regard to the LLNs, we have successfully synthesized nanoparticles around 10 nm of YVO 4 : Eu(III), with high emission in the red spectral region, nanorod and nanowire of TbPO 4 • H 2 O and Eu 1−x Tb x PO 4 • H 2 O, width 5-7 nm and length 300 nm, showing very bright luminescence in green, and core/shell nanosized Eu(III) and Tb(III)/Eu(III) complexes with naphthoyl trifluoroacetone and tri-n-octylphosphineoxide (Eu.NTA.TOPO@PVP, Eu X Tb 1−X .NTA.TOPO). The appropriated core/shell structures can play a double role, one for enhancing luminescence efficiency and another for providing nanophosphors with better stability in water media for facilitating the penetration of nanophosphor core into a biomedical environment.The organic functionalizations of the obtained LLNs were done through their surface encapsulation with a functional polysiloxane including active groups such as amine (NH 2 ), thiocyanate (SCN) or mecarpto (SH). The properties of functional sol-gel matrix have great influence on the luminescence properties, especially luminescence intensity of YVO 4 : Eu(III), Eu.NTA.TOPO@PVP, TbPO 4 • H 2 O and Eu x Tb 1−x PO 4 • H 2 O. Bioconjugation processes of the functionalized LLNs have been studied with some bioactive molecules such as biotin, protein immunoglobulin G (IgG) or bovine serum albumin (BSA).The results of LLN-bioconjugate linking with IgG for recognizing virus (vaccine) will be presented in brief. It is consistent to state that the LLN bioconjugates prepared from YVO 4 : Eu(III)-nanoparticles, TbPO 4 • H 2 O nanorod or wire and EuNTA.TOPO@PVP nanosized core/shell complex could be used as labels for recognizing virus in diagnosis or in vaccine production by use of the fluorescence immunoassay (FIA) method. The fluorescence images of the incubated specimens consisting of LLN bioconjugate and vaccine fabricate could be obtained well in terms of sharpness, reproductivity and stability.

“Rotavin-M1” is an oral live-attenuated vaccine that prevents diarrhea in children under five years old, produced from rotavirus strains G1P [1] on Vero cells. This vaccine has been studied for 16 years beginning with monitoring the local circulating strain and eventually establishing a seed lots system. The safety and immunogenicity of the vaccine were found equivalent to internationally-imported vaccines

The Message Passing Interface (MPI) is a parallel programming model used to exchange data between working units in different nodes of a supercomputer. While MPI blocking operations return when the communication is complete, nonblocking and persistent operations return before the communication is complete, enabling a developer to hide communication latency. However the usage of these latter comes with additional rules the user has to abide to. This is error prone, which makes verification tools valuable for MPI program writers. PARCOACH is a framework that detects MPI collective errors using a static/dynamic analysis. The static phase studies the control-and data-flow of a program to detect potential errors while the dynamic phase uses compile-time information to verify the potential errors. In this paper we present an extension of PARCOACH static analysis to detect misuse of MPI nonblocking and persistent communications. Our new analysis adds the detection of four new error classes related to these types of communications.