Liver abscessation is an important metabolic disorder that commonly afflicts cattle consuming cereal-based, high-concentrate diets. Economic ramifications of liver abscessation are substantial, and include liver condemnation, decreased body weight gain, poorer efficiency of feed utilization, reduced carcass yield, and impairments in operational efficiency of commercial abattoirs. The etiological agent most commonly associated with liver abscesses is Fusobacterium necrophorum , which is an anaerobic, Gram-negative, nonmotile, nonsporulating, and rod-shaped (pleomorphic) bacterium. Fusobacterium necrophorum is one of the major proteolytic species of bacteria in the rumen, and it is believed to have a major role in degradation of dietary lysine. Herein we describe interactions between lysine and F . necrophorum , and the potential role of dietary lysine as an enabling factor in the development of liver abscesses in cattle.

Lysine frequently is cited as the first-limiting amino acid for cattle diets. Synthetic lysine, while routinely added to pig diets, is ineffective in fulfilling lysine requirements of cattle due to extensive degradation by microbes within the rumen. Lysine can be encapsulated with compounds, such as saturated fats, that minimize degradation by ruminal microbes, thereby assuring that a greater proportion of the amino acid is available for absorption post-ruminally. The purpose of this experiment was to measure the impact of SafeGain (H.J. Baker & Bro. Inc., Little Rock, AR), an encapsulated form of lysine sulfate, on rate of gain and feed efficiency in backgrounding cattle.