The outcome of PD in Italy is dependent on hospital volume and a policy of centralization may therefore be appropriate.

PPRs are generally safe and effective procedures for treating small NF-PETs. However, better selection criteria must be identified, and lymph node sampling should be performed routinely to avoid understaging. Long-term follow-up evaluation (>5 years) is of paramount importance given the possible risk of late recurrence.

This study points out the high number of new cases of PETs observed in Italy, with a high prevalence of NF and incidentally discovered forms. The size of the tumor was smaller and the rate of metastasis was lower than usually reported, suggesting a trend toward an earlier diagnosis.

To analyze the characteristics and outcomes following enucleation and pancreatic resections of insulinomas.

This study strongly indicates the fact that surgical resection represents the cornerstone treatment of PETs.