Background: Renal complication in hypereosinophilic syndrome (HES) is rare, with literature scarcely reporting association of this syndrome with glomerular involvement. While the direct effect of eosinophilic infiltration in tissues has been linked to histological damage of the HES, other mechanisms may account for renal involvement too. Case Presentation: We present a case of a 17-year-old male patient, with progressive edema, contact reactive erythematous skin lesions, acute kidney injury, nephrotic syndrome and progressive eosinophilia. His bone marrow biopsy revealed moderate hyperplasia with severe eosinophilia and atypical lymphocytes. His renal biopsy revealed glomeruli, enlarged in volume with mesangial expansion and hypercellularity and segmental thickening of capillary loops. Likewise, some glomeruli showed peripheral hyalinosis with synechiae to Bowman's capsule. Tubules showed cloudy swelling, mild tubular atrophy and hyaline cylinders. Interstitial area showed infiltrated lymphomononuclear cells, focal with no evidence of eosinophils. Blood vessels were unaltered. Immunofluorescence identified glomeruli with granular mesangial IgM deposition. After corticosteroid treatment, eosinophilia and creatinine values regress to normal range. Conclusions: While our case may suggest the coexistence of two unrelated diseases, further studies are required to assess the pathophysiology of glomerular involvement in HES. Given the possibility that mechanisms other than the direct effect of eosinophils are involved in certain patients
Introducción. La biopsia renal percutánea es uno de los procedimientos que más ha contribuido al conocimiento de las enfermedades renales. Nuestro país no cuenta con datos actualizados sobre este tema en específico. Nuestro objetivo es reportar la proporción de los diferentes tipos de la glomerulopatías primarias y secundarias en las biopsias renales ejecutadas por el Servicio de Nefrología del Hospital Nacional Dos de Mayo desde el año 2007 al año 2016. Métodos. Series de casos retrospectivo con revisión de fichas clínicas en el Servicio de Nefrología del Hospital Nacional Dos de Mayo. Se tomó el registro de biopsias renales del Servicio de Nefrología desde el año 2007 al 2016. Se revisaron los resultados de los reportes de biopsias renales, los resultados se reportan en proporciones. Resultados. Se registraron 139 biopsias renales. En relación con las glomerulopatías primarias, la causa más frecuente reportada fue la glomerulonefritis focal y segmentaria luego la glomerulonefritis membranoproliferativa con 50 (36%) y 26 (18,7%) casos respectivamente. Dentro de las glomerulopatías secundarias la causa más frecuente fue nefritis lúpica con 5 (3,6%) casos. Conclusiones. La glomerulonefritis focal y segmentaria es el reporte más frecuente en las biopsias efectuadas en los registros del Hospital Nacional Dos de Mayo. Este resultado se correlaciona con la casuística latinoamericana.
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