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Structural Characterization of Vanchrobactin, a New Catechol Siderophore Produced by the Fish Pathogen Vibrio anguillarum Serotype O2. -(SOENGAS, R. G.; ANTA, C.; ESPADA, A.; PAZ, V.; ARES, I. R.; BALADO, M.; RODRIGUEZ, J.; LEMOS, M. L.; JIMENEZ*, C.; Tetrahedron Lett. 47 (2006) 39, 7113-7116; Dep. Quim. Fundam. Ind., Fac. Cienc., Univ. La Coruna, E-15071 La Coruna, Spain; Eng.) -Mais 03-203

Three new sterols, 5alpha,6alpha-epoxy-24R-ethylcholest-8(14)-en-3beta,7alpha-diol (1), 5alpha,6alpha-epoxy-24R-ethylcholest-8-en-3beta,7alpha-diol (2), and 3beta-hydroxy-24R-ethylcholesta-5,8-dien-7-one (3), have been isolated from the marine sponge Polymastia tenax, collected in the Colombian Caribbean, and their structures established on the basis of extensive NMR and MS studies. Compounds 1 and 2 showed antiproliferative activity toward A-549, HT-29, H-116, MS-1, and PC-3 tumor cells in the range 0.5-10 microg/mL.

The structure drawn for thorectandrol B (2) was incorrectly drawn. The correct structure is as shown below.