Cerebral palsy (CP) is the most common motor disability in childhood, and as far as we know, there are no biometric studies that have evaluated CP and oral health (OH) on a global level. The aim of this study was to present the worldwide research trends in studies of OH in persons with CP, using bibliometric analysis. Through bibliographic information on publications about OH and CP was obtained in the PubMed database, from 1956 to 2021. The extracted data included periodical, title, year of publication, authors, citations, impact factor, key words, country, most cited publications, and study design. A total of 567 articles were published and indexed in PubMed up until 6/28/2021. The data showed a constant growth and an exponential increase in the number of publications. The articles were written in 17 different languages, and 232 (90.63%) articles were in English.  Among the 111 Periodicals, Special Care in Dentistry contributed the most to scientific research with 30 articles (17.3%).  Brazil (25%) and the United States (17.24%) were the countries with the highest number of publications. Observational studies were the most frequent types of articles (76.29%), followed by case reports (13.36%). It was concluded that this current network analysis indicates that although there is a significant growth in the number of publications about OH in persons with CP, it is important to increase the number of interventional randomized clinical trial studies, to include this population in high-impact oral health investigations around the world.

We evaluated the efficacy of xylitol varnishes on the remineralization of newly erupted permanent and deciduous teeth in vitro and in situ. Human enamel specimens were randomly allocated to 8 groups (n = 15/group). Artificial caries lesions were produced and enamel alterations were quantified by surface/subsurface hardness and transverse microradiography. The blocks were then treated with the following varnishes: Duraphat TM ; 20 wt% xylitol (146 μm) varnish; 20 wt% milled xylitol (80 μm) varnish, and placebo varnish, and removed after 6 h of immersion in artificial saliva. In vitro: the blocks were subjected to pH-cycles for 8 days. In situ: fifteen subjects wore palatal appliances containing four pre-demineralized and treated enamel specimens, for 5 days. Data were statistically analyzed by ANOVA/ Tukey and Kruskal-Wallis/Tukey's test (p < 0.05). The %SHR in both studies was significantly increased by xylitol and Duraphat™ varnishes when compared to placebo. Considering subsurface remineralization, only the xylitol varnishes were able to significantly reduce the enamel lesion. Xylitol varnishes can be promising alternatives to promote enamel remineralization of newly erupted permanent and deciduous teeth.

Background: Alzheimer’s Disease (AD) is a neurodegenerative disease responsible for neuronal losses that affect mainly the cortex and hippocampus, which begin to shrink in size, damaging cognitive functions. This process affects cholinergic neurons, influencing acetylcholine (ACH) levels, a memoryrelated neurotransmitter. Glucose metabolism and low thiamine levels appear to be affected by AD. Consequently, diabetes becomes a disease associated with AD and the thiamine deficiency levels depress the use of glucose by the brain. Thus, nutrition may have a role in preventing dementia through the treatment and prevention. Objective: To summarize the knowledge about this topic by reviewing articles and analyzing if healthy eating influences the development of AD. Methods: Selection of articles from the Scielo database. Results: Inflammation contributes to the pathogenesis of AD. The effect observed in patients with adherence to the Mediterranean diet translates into a decrease in inflammatory markers at the plasma level. One of the symptoms, memory loss, can be prevented by a micronutrient named thiamine, a precursor of ACH, it is found in the leguminous. The Mediterranean diet has been shown to attribute a neuroprotective activity which goes with its anti-inflammatory effect. Conclusion: AD starts by its multifactorial etiology that consists of genotype and phenotype. Nutrition would be efficient as a preventive and a therapeutic alternative among other.

Cerebral Palsy (CP) is a limiting deficiency, characterized by a permanent neuromotor disorder which affects movements, resulting in non-progressive lesions of the immature brain during the neuro psychomotor stages. Epidemiological studies of premature births correlated with the presence of high levels of inflammation in the umbilical cord, amniotic fluid, and fetal blood, being that one of the most relevant underlying physiopathological mechanisms includes inflammation and intra-amniotic infection, with inflammatory response and damage to the developing brain. Recently attributed to the excessive production of cytokines, CP inflammation is mostly modulated through diet restriction, intestinal dysfunction, and drug intake. The high prevalence of convulsive crises in individuals with CP (77%) on its own does not bring about post inflammatory and post convulsive cytokine synthesis, treated with antiepileptic medication. In these individuals, there is high incidence of intestinal constipation (47%), besides oral dysbiosis, gingival bleeding and even greater increase in chronic inflammation. The dysbiosis causes an increase in mucous permeability (leaky-gut) of the gut-brain axis, and increase in seric endotoxin, demonstrating a persistent inflammatory state, and supporting the emergence of new side effects, which can become the object of future research.

Familiar to high-end smartphones users around the world, location based applications are scarce or even unseen on major low-end feature phones. There are many reasons for that, such as, lack of developers interest on those platforms, absence of location-aware hardware, low rate of mobile data plans adoption by its users, difficulties to develop for low-end devices and poor hardware specifications to handle a fast and informative application with complex data.