No abstract

A series of novel amide functionalized trifluoromethyl substituted pyridine derivatives were prepared starting from pyridine 1 on reaction with bromoethylacetate followed by reaction with different primary aliphatic amines, cyclic secondary amines or L-amino acids under different set of conditions. All the synthesized compounds 4a-j and 5a-d were screened for anticancer activity against four cancer cell lines such as HeLa-Cervical cancer (CCL-2), COLO 205-Colon cancer (CCL-222) HepG2- Liver cancer (HB-8065), MCF7-Breast cancer (HTB-22). 4j and 5d showed good activity.