In this manuscript, an Adaptive and Efficient Hybrid In-loop Filter based on Enhanced Generative Adversarial Network Deblocking Filter (EGANDF) with Sample Adaptive Offset filter (EGANDF-SAO-HEVC) is proposed for High Efficiency Video Coding (HEVC)/H-265. In this, the proposed hybrid in-loop filter involves EGANDF and Sample Adaptive Offset (SAO) filter that lessens the blocking artifacts caused by block-wise processing for coding unit (CU), which is mainly used for improving the video quality. Initially, EGANDF is proposed for HEVC/H-265 for removing blocking artifacts along low computation. Here, the output of EGANDF is given to the SAO filter for reducing ringing artifacts by diminishing high-frequency components during quantization. Thus, the proposed method efficiently reduces artifacts for improving video quality performance. The proposed EGANDF-SAO-HEVC method is implemented in the working platform of HEVC reference software with MATLAB. Finally, the proposed EGANDF-SAO-HEVC model has attained 27.26%, 29.65%, 12.45% higher accuracy, 33.56%, 31.8%, 28.7% higher sensitivity, 34.7%, 33.5%, 32.6% higher specificity, 46.92%, 35.7%, 41.3% lower MSE, 25.7%, 29.7%, 35.6% higher PSNR, and 25.6%, 28.9%, 13.6% higher SSIM for using basketball video sequence when compared to the existing methods.