FNAC is highly cost effective, patient friendly outpatient procedure with minimal discomfort and gives basic to accurate information regarding the lesions. It is considered as first line investigative technique as it gives quick results with good sensitivity and specificity. It also stratifies cases requiring further investigations, surgical intervention or just clinical follow-up. Present study is about the profile of non-neoplastic and neoplastic thyroid lesions by Fine needle aspiration cytology and correlates the FNAC findings with the histopathology. This study was undertaken in the

Introduction: Clinical, morphological, immunophenotypic, genetic and molecular characteristics are the most important diagnostic modalities in established diagnosis of acute leukemia. Immuno phenotyping flow cytometry has become a proven valuable tool for precise characterization of acute leukemia. This study was done to see various types of acute leukemia and aberrant antigen expression pattern in acute leukemia in patients and also to compare the results between microscopic morphology and flow cytometry. Materials and Methods: Total number of acute leukemia diagnosed was 103 and of all the age groups. All the new cases reported which were showing atypical cells in peripheral smear and treated cases to find out the minimal residual disease (MRD) were included in this study. Results: When the immune phenotyping of the acute lymphocytic leukemia patterns was done, most of the B-ALL showed positivity for CD79 alpha and HLA-DR followed by other markers and most of the T-ALL showed positivity for CD3 and CD7 markers followed by other markers. When the immune phenotyping patterns of acute myeloid leukemia was done, almost all the cases showed positive for CD13 and varying degrees of positivity with other markers. Conclusion:The flow cytometry immune phenotyping is a powerful tool for accurate diagnosis of acute leukemias and also help in identifying myeloid or lymphoid lineage of these leukemias and has great prognostic and therapeutic implications.