Hormonal change in endocrine glands leads to metabolic syndrome. Latest research work suggests that nearly 40-50% of peoples only from USA suffer due to metabolic syndrome. Sedentary lifestyle leads to metabolic syndrome. Commonly seen metabolic syndromes are cardio-metabolic syndrome, syndrome X, insulin resistance syndrome, Reaven's syndrome which leads to diabetes, Obesity, pancreatic disorders, etc. Hormone like insulin, which is produced from β-cells of pancreas plays vital role in metabolic syndrome. Not only insulin but metals (Arsenic, cadmium, copper, lead, manganese, molybdenum, iodine) and proteins also have major role in metabolic syndrome. Metabolic syndrome percentage is more in women than that of men. The patients who are suffering from HIV, they commonly have metabolic syndromes. Dietary habit and sedentary lifestyle is a one of the causes for the metabolic syndrome. Metabolic Syndrome Insulin resistance Central obesity Glucose intolerance Dyslipidemia with elevated triglycerides Low HDLcholesterol Osteoporosis Hypertension Endothelial Dysfunction Oxidative stress Inflammation Related disorders of polycystic ovarian syndrome fatty liver disease (NASH) and gout Predominance of small dense LDL-cholesterol particles Figure 1: Related Disorders in metabolic Syndrome J ou rna l o f D ia be tes & M e ta bolism

Cancer is deadly disease which is caused due to uncontrolled growth of the cells and forms from the extra mass tissue known as tumour. The loss of apoptotic nature by the cells in their metabolic pathway leads to cancer. Cigarette smoking, tobacco intake, alcohol intake, poor diet and exposure to UV rays lead to cancer. Different organs can be effect by cancer cells like lungs, kidney, eyes, heart, brain etc. Cancer cells also spread in blood stream and causes blood cancer. The person who works in the chemical factories, nuclear reactors, drainage system and mining are most prone to cancer. The most cancer causing agents are aluminium, arsenic, radon, lead and lead compounds, titanium dioxide, Ethidium Bromide, Cobalt with tungsten carbide, Welding fumes and Indium phosphide. Treatments such as surgery, chemotherapy and radiation therapy, bone marrow transplantation are used to treat cancer in different stages.