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INTRODUCTIONElastomers are long and highly flexible polymer network with cross-linking between them. The high mobility of these polymer chains, which can reconfigure on stress is attributed to the flexible chain length, whereas the elasticity and mechanical strength is attributed to the cross linking. The combinations of these properties make them suitable as biomaterials in medical fields [1]. Aliphatic polyester elastomers can mimic the tissues in our body, as they can be tailored to give a wide range of physiochemical, mechanical and degradative properties [2,3]. So the focus on synthesis, characterization and application of biodegradable polyester elastomers are drastically increasing and they have emerged as a vital class of biomaterials. These elastomers are relatively beneficial as they can be produced at a lower cost with controlled properties.Many such elastomers have been synthesized in the past, such as poly(glycerol sebacate) [4,5] Biodegradable polyester elastomers have gained a greater attention in the field of skin tissue engineering. A series of novel biodegradable polyesters are synthesized, based on non toxic monomers e.g., aconitic acid, citric acid and 1,12-dodoecanediol, which are usually extracted from natural components. In the present work, a co-polyester poly (1,12-dodecanediol acotinate-co-1,12-dodecanediol citrate) (PACDDL) is synthesized by melt poly-condensation without any toxic catalyst. The chemical structure of the elastomers are then characterized by FT-IR, 1 H NMR and 13 C NMR. TGA, DSC techniques. The biological studies such as, in vitro cyto-compatibility, anticancer activity and CAM assay (angiogenesis) are examined. The physical properties exhibit that the elastomer is suitable for application in tissue engineering. The biological studies reveal that the polymer has excellent cell compatibility, making it suitable as potent biomaterial in skin tissue engineering.