Medicinal plants have been used basically in all cultures as a source of medicine. Medicinal plants play an important role in public health, especially in developed and developing countries and leads to examination for therapeutic and pharmacological applications. Medicinal Plants have been used for thousands of years to flavor and conserve food, to treat different health issues and to prevent diseases including epidemics. Active compounds produced during secondary metabolism are usually posses the biological properties of plant species used throughout the globe for various purposes, including treatment of infectious diseases. Based on the medicinal values, the Celosia species has been chosen for this study. Celosia species plays an important role in traditional medicine to cure several disorders such as fever, diarrohea, mouth sores, itching, wounds, jaundice, gonorrhea, and inflammation. A variety of phytoconstituents are isolated from the Celosia species which includes triterpenoids, saponins, alkaloids, phenols, tannins, flavonoids, cardiac glycosides, steroids, phytosterols, and phlobatannins. The plant having potential pharmacological values screened for its various pharmacological activities, namely, anti-inflammatory, immune-stimulating, anticancer, hepatoprotective, antioxidant, wound healing, antidiabetic, antinociceptive effect and antibacterial activities which are reported in the extracts of different parts of the plant. The objective of this study was to provide an overview of the ecology, phytoconstituents, pharmacology of Celosia species and to confess their therapeutic potentials and secure an evidence base for further research works on Celosia.

Objectives: Bioactive phytocompounds are a rich source of chemopreventive substance. In the present investigation, docking study was performed for the selected bioactive phytocompounds such as oleanolic acid, ecdysterone, betaine, stigmasterol acetate, and cinnamic acid to evaluate their affinity to glycogen synthase kinase-3 beta (GSK-3β) protein, a wound-healing biomarker. 2-chloro-5-[4-(3-chloro-phenyl)-2, 5-dioxo-2,5-dihydro-1h-pyrrol-3-ylamino]-benzoic acid was used as an inhibitor for GSK-3β with minimum binding energy (−31.5 kcal/mol).Methods: Molecular docking study was conducted using AutoDock 4.2 version and the visualization result using Discover Studio 4.5. Results:The docking analysis ranked the selected phytocompounds that have high theoretical scores to bind to the proteins. The binding mode of the phytocompounds that bound to all the target proteins with high affinity was studied. The simulation demonstrated that the protein-ligand complex stabilized by multiple hydrogen bonds (H-bonds) was preferentially formed at the catalytic site. The results highlighted in this study reveals that among the selected lead phytocompounds that docked into the active site of GSK-3β, ecdysterone showed acceptable 6 H-bond interactions with residues LYS85, TYR134, ARG141, GLN185, ASP200, PRO136 when compared to the reference compound with 5 H-bond interactions. Conclusion:Thus, based on the docking score ecdysterone could be considered as a novel compounds that can be used for experimental studies for the inhibition of GSK-3β kinase. These results can be helpful for further design of novel GSK-3β inhibitors.

Herbal plants and phytogenic products have used for the treatment of various diseases from ancient times in the folklore medicine worldwide. Crude extracts from plants now play an important and valuable source for natural products that are used in the advancement of medicines against various diseases, for the improvement of pharmaceutical preparations and for novel bioscience research. One such plant genus is Annona, such as Annona muricata, Annona cherimola, Annona reticulata, Annona squamosa, and Annona senegalensis are some species widely cultivating in India and tropical regions of Asia for their edible fruits and medicinal values. These plants have been used for centuries as traditional folk medicine for the treatments of various diseases. The plants are considered to be a good source of vitamins, minerals, plant proteins, fibers, etc., as well as the plant is supposed to have many biological activities. This review describes the morphology and ecology of the plant, its ethnomedicinal uses, pharmacological activities, and phytoconstituents.